Drug discovery for neglected tropical diseases is carried out using both target-based and
phenotypic approaches. In this paper, target-based approaches are discussed, with a …

Invasive mycoses have become important causes of morbidity and mortality in
immunocompromised patients. New approaches for antifungal therapy are required to meet …

N-terminal N-myristoylation is a lipid anchor modification of eukaryotic and viral proteins
targeting them to membrane locations, thus changing the cellular function of modified …

The C-4 side chain modification of lead compound 1 has resulted in the identification of a
potent and selective Candida albicans N-myristoyltransferase (CaNmt) inhibitor RO-09 …

N-Myristoyltransferase (NMT) represents a promising drug target for human African
trypanosomiasis (HAT), which is caused by the parasitic protozoa Trypanosoma brucei. We …

N-myristoyltransferase (Nmt) attaches myristate to the N-terminal glycine of many important
eukaryotic and viral proteins. It is a target for anti-fungal and anti-viral therapy. We have …

Myristoyl-CoA: protein N-myristoyltransferase (Nmt) is a monomeric enzyme that catalyzes
the transfer of the fatty acid myristate from myristoyl-CoA to the N-terminal glycine residue of …

N-myristoyltransferases (NMT) add myristate to the NH2 termini of certain proteins, thereby
regulating their localization and/or biological function. Using RNA interference, this study …

In recent years, many new immunologically active peptides from insects have been
identified. Unfortunately, in most cases, their physiological functions are not fully known. One …

Crystallography has guided the hybridization of two series of Trypanosoma brucei N-
myristoyltransferase (NMT) inhibitors, leading to a novel highly selective series. The effect of …