Inhibition of glycogen synthase kinase 3 by lithium, a mechanism in search of specificity
D Chatterjee, JM Beaulieu - Frontiers in Molecular Neuroscience, 2022 - frontiersin.org
Inhibition of Glycogen synthase kinase 3 (GSK3) is a popular explanation for the effects of
lithium ions on mood regulation in bipolar disorder and other mental illnesses, including …
lithium ions on mood regulation in bipolar disorder and other mental illnesses, including …
Dysregulation of CRMP2 post-translational modifications drive its pathological functions
A Moutal, KA White, A Chefdeville, RN Laufmann… - Molecular …, 2019 - Springer
Collapsin response mediator proteins (CRMPs) are a family of ubiquitously expressed,
homologous phosphoproteins best known for coordinating cytoskeletal formation and …
homologous phosphoproteins best known for coordinating cytoskeletal formation and …
Stimulus‐dependent modifications in astrocyte‐derived extracellular vesicle cargo regulate neuronal excitability
Extracellular vesicles have now emerged as key players in cell‐to‐cell communication. This
is particularly important in the central nervous system, where glia–neuron cross‐talk helps …
is particularly important in the central nervous system, where glia–neuron cross‐talk helps …
Epitranscriptomic regulation of cortical neurogenesis via Mettl8-dependent mitochondrial tRNA m3C modification
Increasing evidence implicates the critical roles of various epitranscriptomic RNA
modifications in different biological processes. Methyltransferase METTL8 installs 3 …
modifications in different biological processes. Methyltransferase METTL8 installs 3 …
Synapse-enriched m6A-modified Malat1 interacts with the novel m6A reader, DPYSL2, and is required for fear-extinction memory
The RNA modification N6-methyladenosine (m6A) regulates the interaction between RNA
and various RNA binding proteins within the nucleus and other subcellular compartments …
and various RNA binding proteins within the nucleus and other subcellular compartments …
Probing the lithium-response pathway in hiPSCs implicates the phosphoregulatory set-point for a cytoskeletal modulator in bipolar pathogenesis
BTD Tobe, AM Crain, AM Winquist… - Proceedings of the …, 2017 - National Acad Sciences
The molecular pathogenesis of bipolar disorder (BPD) is poorly understood. Using human-
induced pluripotent stem cells (hiPSCs) to unravel such mechanisms in polygenic diseases …
induced pluripotent stem cells (hiPSCs) to unravel such mechanisms in polygenic diseases …
Risk assessment analysis for maternal autoantibody-related autism (MAR-ASD): a subtype of autism
The incidence of autism spectrum disorder (ASD) has been rising, however ASD-risk
biomarkers remain lacking. We previously identified the presence of maternal …
biomarkers remain lacking. We previously identified the presence of maternal …
Maternal autoantibody profiles as biomarkers for ASD and ASD with co-occurring intellectual disability
A Ramirez-Celis, LA Croen, CK Yoshida… - Molecular …, 2022 - nature.com
Maternal autoantibody-related ASD (MAR ASD) is a subtype of autism in which pathogenic
maternal autoantibodies (IgG) cross the placenta, access the developing brain, and cause …
maternal autoantibodies (IgG) cross the placenta, access the developing brain, and cause …
New insights on synaptic dysfunction in neuropsychiatric disorders
GL Caldeira, J Peça, AL Carvalho - Current opinion in neurobiology, 2019 - Elsevier
Highlights•Genetic and functional studies have provided important evidence pointing toward
a central role for dendritic spines on the pathogenesis of neuropsychiatric conditions.•Many …
a central role for dendritic spines on the pathogenesis of neuropsychiatric conditions.•Many …
A role of low-density lipoprotein receptor-related protein 4 (LRP4) in astrocytic Aβ clearance
Amyloid-β (Aβ) deposition occurs years before cognitive symptoms appear and is
considered a cause of Alzheimer9s disease (AD). The imbalance of Aβ production and …
considered a cause of Alzheimer9s disease (AD). The imbalance of Aβ production and …