Extracellular matrix regulation of inflammation in the healthy and injured spinal cord
AD Gaudet, PG Popovich - Experimental neurology, 2014 - Elsevier
Throughout the body, the extracellular matrix (ECM) provides structure and organization to
tissues and also helps regulate cell migration and intercellular communication. In the injured …
tissues and also helps regulate cell migration and intercellular communication. In the injured …
Matrix metalloproteinase-2 and-9 as promising benefactors in development, plasticity and repair of the nervous system
M Verslegers, K Lemmens, I Van Hove… - Progress in neurobiology, 2013 - Elsevier
It has been 50years since Gross and Lapiere discovered collagenolytic activity during
tadpole tail metamorphosis, which was later on revealed as MMP-1, the founding member of …
tadpole tail metamorphosis, which was later on revealed as MMP-1, the founding member of …
[HTML][HTML] Role of matrix metalloproteinases and therapeutic benefits of their inhibition in spinal cord injury
This review will focus on matrix metalloproteinases (MMPs) and their inhibitors in the context
of spinal cord injury (SCI). MMPs have a specific cellular and temporal pattern of expression …
of spinal cord injury (SCI). MMPs have a specific cellular and temporal pattern of expression …
Inhibition of MMP‐3 or‐9 suppresses lipopolysaccharide‐induced expression of proinflammatory cytokines and iNOS in microglia
MS Woo, JS Park, IY Choi, WK Kim… - Journal of …, 2008 - Wiley Online Library
Recently, matrix metalloproteinases (MMPs) are emerging as important molecules in
neuroinflammation as well as neuronal cell death. However, the role of MMPs in activated …
neuroinflammation as well as neuronal cell death. However, the role of MMPs in activated …
The systemic inflammatory response after spinal cord injury damages lungs and kidneys
Spinal cord injury (SCI) triggers a well characterized, acute, local inflammation leading to
secondary damage at the lesion site. Another little recognized problem may be the activation …
secondary damage at the lesion site. Another little recognized problem may be the activation …
Matrix metalloproteinase in blood-brain barrier breakdown in dementia
EM Weekman, DM Wilcock - Journal of Alzheimer's Disease, 2016 - content.iospress.com
The neurovascular unit, which consists of astrocytic end-feet, neurons, pericytes, and
endothelial cells, plays a key role in maintaining brain homeostasis by forming the blood …
endothelial cells, plays a key role in maintaining brain homeostasis by forming the blood …
Role of platelets in neuroinflammation: a wide-angle perspective
LL Horstman, W Jy, YS Ahn, R Zivadinov… - Journal of …, 2010 - Springer
Objectives This review summarizes recent developments in platelet biology relevant to
neuroinflammatory disorders. Multiple sclerosis (MS) is taken as the" Poster Child" of these …
neuroinflammatory disorders. Multiple sclerosis (MS) is taken as the" Poster Child" of these …
Inhibition of MMP-9 by a selective gelatinase inhibitor protects neurovasculature from embolic focal cerebral ischemia
J Cui, S Chen, C Zhang, F Meng, W Wu, R Hu… - Molecular …, 2012 - Springer
Background Cerebral ischemia has been shown to induce activation of matrix
metalloproteinases (MMPs), particularly MMP-9, which is associated with impairment of the …
metalloproteinases (MMPs), particularly MMP-9, which is associated with impairment of the …
Ephrin-B2-induced Cleavage of EphB2 Receptor Is Mediated by Matrix Metalloproteinases to Trigger Cell Repulsion∗
EphB receptors provide crucial adhesive and repulsive signals during cell migration and
axon guidance, but it is unclear how they switch between these opposing responses. Here …
axon guidance, but it is unclear how they switch between these opposing responses. Here …
Matrix metalloproteinases in neuropathic pain and migraine: friends, enemies, and therapeutic targets
SE Lakhan, M Avramut - Pain Research and Treatment, 2012 - Wiley Online Library
Matrix metalloproteinases (MMPs) constitute a family of zinc‐dependent endopeptidases
that mediate extracellular matrix turnover and associated processes, such as cell survival …
that mediate extracellular matrix turnover and associated processes, such as cell survival …