Heat shock proteins (HSP) are a subset of the molecular chaperones, best known for their
rapid and abundant induction by stress. HSP genes are activated at the transcriptional level …

GATA1 is considered as the “master” transcription factor in erythropoiesis. It regulates at the
transcriptional level all aspects of erythroid maturation and function, as revealed by gene …

Acetylation of histones triggers association with bromodomain-containing proteins that
regulate diverse chromatin-related processes. Although acetylation of transcription factors …

Heat shock proteins (HSPs) are chaperones that catalyze the proper folding of nascent
proteins and the refolding of denatured proteins. The ubiquitinproteasome system is an …

Small heat shock proteins (sHsps) regulate a large number of fundamental cellular
processes and are involved in many pathological diseases. They share complex …

The inhibition of heat shock protein 70 (HSP70) is an emerging strategy in cancer therapy.
Unfortunately, no specific inhibitors are clinically available. By yeast two-hybrid screening …

Constitutively expressed small heat shock protein HspB1 regulates many fundamental
cellular processes and plays major roles in many human pathological diseases. In that …

SF3B1 is the most frequently mutated RNA splicing factor in cancer, including in∼ 25% of
myelodysplastic syndromes (MDS) patients. SF3B1-mutated MDS, which is strongly …

Human small heat shock proteins are molecular chaperones that regulate fundamental
cellular processes in normal unstressed cells as well as in many cancer cells where they are …

Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by myofibroblast
proliferation. Transition of epithelial/mesothelial cells into myofibroblasts [epithelialto …