Neuroinflammation in animal models of traumatic brain injury

CC Chiu, YE Liao, LY Yang, JY Wang… - Journal of neuroscience …, 2016 - Elsevier
Traumatic brain injury (TBI) is a leading cause of mortality and morbidity worldwide.
Neuroinflammation is prominent in the short and long-term consequences of neuronal …

Pathophysiological responses and roles of astrocytes in traumatic brain injury

S Michinaga, Y Koyama - International journal of molecular sciences, 2021 - mdpi.com
Traumatic brain injury (TBI) is immediate damage caused by a blow to the head resulting
from traffic accidents, falls, and sporting activity, which causes death or serious disabilities in …

A systematic review of closed head injury models of mild traumatic brain injury in mice and rats

CN Bodnar, KN Roberts, EK Higgins… - Journal of …, 2019 - liebertpub.com
Mild TBI (mTBI) is a significant health concern. Animal models of mTBI are essential for
understanding mechanisms, and pathological outcomes, as well as to test therapeutic …

Elevated serum levels of inflammation-related cytokines in mild traumatic brain injury are associated with cognitive performance

Y Sun, L Bai, X Niu, Z Wang, B Yin, G Bai… - Frontiers in …, 2019 - frontiersin.org
Mild traumatic brain injury (mTBI) is the most common neurological insult and leads to long-
lasting cognitive impairments. The immune system modulates brain functions and plays a …

Chronic pain after traumatic brain injury: pathophysiology and pain mechanisms

KA Irvine, JD Clark - Pain medicine, 2018 - academic.oup.com
Background Traumatic brain injury refers to a broad range of neurological, cognitive, and
emotional factors that result from the application of an external force to the head. Individuals …

Repetitive model of mild traumatic brain injury produces cortical abnormalities detectable by magnetic resonance diffusion imaging, histopathology, and behavior

F Yu, DK Shukla, RC Armstrong, CM Marion… - Journal of …, 2017 - liebertpub.com
Noninvasive detection of mild traumatic brain injury (mTBI) is important for evaluating acute
through chronic effects of head injuries, particularly after repetitive impacts. To better detect …

Astrocyte‐mediated mechanisms contribute to traumatic brain injury pathology

C Muñoz‐Ballester, S Robel - WIREs Mechanisms of Disease, 2023 - Wiley Online Library
Astrocytes respond to traumatic brain injury (TBI) with changes to their molecular make‐up
and cell biology, which results in changes in astrocyte function. These changes can be …

Voxel-wise comparisons of cellular microstructure and diffusion-MRI in mouse hippocampus using 3D Bridging of Optically-clear histology with Neuroimaging Data …

HB Stolp, G Ball, PW So, JD Tournier, M Jones… - Scientific reports, 2018 - nature.com
A key challenge in medical imaging is determining a precise correspondence between
image properties and tissue microstructure. This comparison is hindered by disparate scales …

Experimental designs for repeated mild traumatic brain injury: challenges and considerations

AN Bolton-Hall, WB Hubbard… - Journal of neurotrauma, 2019 - liebertpub.com
Mild traumatic brain injury (mild TBI) is a growing public concern, as evidence mounts that
even brain injuries classified as “mild” can result in persistent neurological dysfunction …

Structural neuroimaging in sport-related concussion

ED Bigler - International journal of psychophysiology, 2018 - Elsevier
Structural neuroimaging of athletes who have sustained a sports-related concussion (SRC)
can be viewed as either standard clinical imaging or with advanced neuroimaging methods …