Epidemiological studies established that elevated homocysteine, an important intermediate
in folate, vitamin B 12, and one carbon metabolism, is associated with poor health, including …

This review is concerned with the role of fibrillization of the amyloid β (Aβ)-peptide in
Alzheimer's disease (AD). The perspective is that of a physical chemist, and one aim is to …

Abstract Characterization of the genetic landscape of Alzheimer's disease (AD) and related
dementias (ADD) provides a unique opportunity for a better understanding of the associated …

A growing body of evidence suggests that dysbiosis of the human gut microbiota is
associated with neurodegenerative diseases like Alzheimer's disease (AD) via …

General cognitive function is a prominent and relatively stable human trait that is associated
with many important life outcomes. We combine cognitive and genetic data from the …

Alzheimer's disease (AD) is a progressive neurodegenerative disease in which the
formation of extracellular aggregates of amyloid beta (Aβ) peptide, fibrillary tangles of …

Abstract The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide
association study of late-onset Alzheimer disease using a three-stage design consisting of a …

P4-ATPases comprise a family of P-type ATPases that actively transport or flip phospholipids
across cell membranes. This generates and maintains membrane lipid asymmetry, a …

We undertook a two-stage genome-wide association study (GWAS) of Alzheimer's disease
(AD) involving over 16,000 individuals, the most powerful AD GWAS to date. In stage 1 …

The gene encoding apolipoprotein E (APOE) on chromosome 19 is the only confirmed
susceptibility locus for late-onset Alzheimer's disease. To identify other risk loci, we …