In the past decade, nonalcoholic fatty liver disease (NAFLD) has become a leading cause of
chronic liver disease and cirrhosis, as well as an important risk factor for hepatocellular …

Immunotherapies targeting conventional T cells have revolutionized systemic treatment for
many cancers, yet only a subset of patients benefit from these approaches. A better …

Liver fibrosis, as an excess deposition of extracellular matrix (ECM) components, results
from chronic liver injury as well as persistent activation of inflammatory response and of …

Cell-based immunotherapy has become the new-generation cancer medicine, and" off-the-
shelf" cell products that can be manufactured at large scale and distributed readily to treat …

Three subsets of invariant natural killer T (iNKT) cells have been identified, NKT1, NKT2,
and NKT17, which produce distinct cytokines when stimulated, but little is known about their …

Summary Interleukin‐15 (IL‐15) exerts many biological functions essential for the
maintenance and function of multiple cell types. Although its expression is tightly regulated …

A number of approaches have been utilized in the prevention, management, and treatment
of obesity, including, surgery, medication, diet, exercise, and overall lifestyle changes …

Invariant natural killer T (iNKT) cells are a group of innate-like T lymphocytes that recognize
lipid antigens. They are supposed to be tissue resident and important for systemic and local …

Chimeric antigen receptor anti-CD19 (CAR19)-T cell immunotherapy-induced clinical
remissions in CD19+ B cell lymphomas are often short lived. We tested whether CAR19 …

Glioblastomas (GBs) are the most aggressive form of primary brain cancer and virtually
incurable. Accumulation of regulatory T (T reg) cells in GBs is thought to contribute to the …