Cellular interactions with the extracellular matrix and with neighboring cells profoundly
influence a variety of signaling events including those involved in mitogenesis, survival, and …

Recent studies of platelet endothelial cell adhesion molecule-1 (PECAM-1 [CD31])-deficient
mice have revealed that this molecule plays an important role in controlling the activation …

Macrophage recognition and ingestion of 'self'cells undergoing apoptosis in vivo protects
tissues from the toxic contents of dying cells and modulates macrophage regulation of …

Migration of leukocytes into tissue is a key element of innate and adaptive immunity. While
the capturing of leukocytes to the blood vessel wall is well understood, little is known about …

Leukocyte migration from the blood into tissues is vital for immune surveillance and
inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell …

Neutrophil emigration in the lung differs substantially from that in systemic vascular beds
where extravasation occurs primarily through postcapillary venules. Migration into the …

Platelet endothelial cell adhesion molecule (PECAM)-1 has been implicated in
angiogenesis, but a number of issues remain unsettled, including the independent …

Integrin-mediated leukocyte adhesion is a critical aspect of leukocyte function that is tightly
regulated by diverse stimuli, including chemokines, antigen receptors, and adhesion …

Platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) is a cell adhesion and
signaling receptor that is expressed on hematopoietic and endothelial cells. PECAM-1 is …

The phosphoinositide phosphatase SHIP is a critical regulator of immune cell activation.
Despite considerable study, the mechanisms controlling SHIP activity to ensure balanced …