Metastatic colorectal cancers (mCRCs) are clinically heterogeneous, but the genomic basis
of this variability remains poorly understood. We performed prospective targeted sequencing …

Colorectal tumors have been classified based on histologic factors, genetic factors, and
consensus molecular subtypes, all of which affect the tumor microenvironment. Elements of …

Aneuploidy, the unbalanced state of the chromosome content, represents a hallmark of most
solid tumors, including colorectal cancer. Such aneuploidies result in tumor specific genomic …

Background Clinical studies regarding colorectal cancer (CRC) have suggested differences
in metastatic patterns between mucinous adenocarcinoma (MC), signet-ring cell carcinoma …

Survival rates of cancer patients vary widely within and between malignancies. While
genetic aberrations are at the root of all cancers, individual genomic features cannot explain …

In contrast to primary colorectal cancer (CRC) little is known about the genomic landscape of
metastasized CRC. Here we present whole genome sequencing data of metastases of 429 …

Purpose: The liver is the most frequent metastatic site for colorectal cancer. Its
microenvironment is modified to provide a niche that is conducive for colorectal cancer cell …

Right-sided colon cancer (RCC) has worse prognosis compared to left-sided colon cancer
(LCC) and rectal cancer. The reason for this difference in outcomes is not well understood …

Increased copy number alterations (CNAs) indicative of chromosomal instability (CIN) have
been associated with poor cancer outcome. Here, we study CNAs as potential biomarkers of …

Chromosomal instability is a well-defined hallmark of tumor aggressiveness and metastatic
progression in colorectal cancer. The magnitude of genetic heterogeneity among distinct …