Organofluorine chemistry is an area of tremendous expansion. 1 The field of applications is
impressively wide in scope and has the potential to concern all fields of society. Indeed …

Trifluomethylated organic compounds often have properties that make them suitable for
diverse applications, including materials science, agrochemistry, and pharmaceutical …

Fluorinated motifs are frequently encountered in drugs and agrochemicals. Incorporating
fluorine-containing motifs in drug candidates for lead optimization in pharmaceutical …

The last two decades have witnessed the emergence of direct enolization protocols
providing atom-economical and operationally simple methods to use enolates for …

The development of new methodologies that enable chemo-and stereoselective
construction of fluorinated substituents, such as the trifluoromethyl (CF3) group, plays an …

Despite the burgeoning demand for fluorine‐containing chemical entities, the construction of
CF3‐containing stereogenic centers has remained elusive. Herein, we report the strategic …

The introduction of the CF3 unit is a common strategy for modifying pharmacokinetic
properties and slowing metabolic degradation in medicinal chemistry. A catalytic and …

Fluorinated ketones are intriguing compounds in synthetic chemistry and life science‐
related fields. The development of efficient methodologies to obtain these compounds is of …

The employment of α-trifluoromethyl α, β-unsaturated esters as dipolarophiles pose
considerable challenge due to expeditious defluorination and intrinsic steric hindrance. The …

Due to the unique steric and electronic nature of the fluorine atom, organofluorine
compounds have received significant attention in the fields of pharmaceuticals and …