PCSK9 inhibitors in cancer patients treated with immune-checkpoint inhibitors to reduce cardiovascular events: new frontiers in cardioncology

V Quagliariello, I Bisceglia, M Berretta, M Iovine… - Cancers, 2023 - mdpi.com
Simple Summary Atherosclerosis is a critical cardiovascular disease associated with the use
of immune checkpoint inhibitors (ICIs). Proprotein convertase subtilisin/kexin type 9 (PCSK9) …

Tales from the future—nuclear cardio-oncology, from prediction to diagnosis and monitoring

N Mikail, R Chequer, A Imperiale… - European Heart …, 2023 - academic.oup.com
Cancer and cardiovascular diseases (CVD) often share common risk factors, and patients
with CVD who develop cancer are at high risk of experiencing major adverse cardiovascular …

A novel speckle‐tracking echocardiography parameter assessing left ventricular afterload

K Sato, K Wildi, J Chan, C Palmieri… - European Journal of …, 2024 - Wiley Online Library
Background Left ventricular stroke work index (LVSWI) and afterload‐related cardiac
performance (ACP) consider left ventricular (LV) afterload and could be better …

Circulating biomarkers in the diagnosis and prognosis of immune checkpoint inhibitor-related myocarditis: time for a risk-based approach

G Murtagh, C deFilippi, Q Zhao, A Barac - Frontiers in Cardiovascular …, 2024 - frontiersin.org
Immune checkpoint inhibitors (ICIs) are monoclonal antibodies that block immune
checkpoints and therefore activate immune cells, allowing them to recognize and attack …

Recent Advances in the Use of Echocardiography in Cardio-Oncology

M El-Rayes, M Sooriyakanthan, H Abdel-Qadir… - … Treatment Options in …, 2023 - Springer
Purpose of review To review recent data regarding the value of echocardiography in the
assessment of patients receiving cancer therapy. Recent findings For the first time …

Extensive CArdioVAscular Characterization and Follow-Up of Patients Receiving Immune Checkpoint Inhibitors: A Prospective Multicenter Study

D Delombaerde, J De Sutter, L Croes, D Vervloet… - Pharmaceuticals, 2023 - mdpi.com
Background: The increasing use of immune checkpoint inhibitors (ICIs) in the treatment of
both advanced and early stages of various malignancies has resulted in a substantial …

Relation of myocardial dysfunction to biomarkers, COVID‐19 severity and all‐cause mortality

J Chen, L Jin, M Zhang, L Wu, C Shen, J Sun… - ESC Heart …, 2024 - Wiley Online Library
Aims The COVID‐19 infection has been described as affecting myocardial injury. However,
the relation between left ventricular global longitudinal strain (GLS), global circumferential …

Complete heart block is a significant predictor of mortality in immune checkpoint inhibitor myocarditis

MP O'Shea, SA Karikalan, A Yusuf, T Barry, E Habib… - Cardio-Oncology, 2023 - Springer
Background Immune checkpoint inhibitor (ICI) myocarditis is associated with significant
mortality risk. Electrocardiogram (ECG) changes in ICI myocarditis have strong prognostic …

[HTML][HTML] Myocardial Strain Is Not in Vain: Predicting Cardiovascular Risk in Checkpoint Inhibitor Myocarditis

B Ky, NS Wilcox - Cardiovascular Imaging, 2022 - jacc.org
checkpoint inhibitors(ICIs) have dramatically changed the landscape of cancer care, with
substantial benefits in survival, but carry a clinically important risk of immune-related …

Using CMR targets of inflammation to develop disease-modifying treatment

RY Kwong, Y Chandrashekhar - Cardiovascular Imaging, 2023 - jacc.org
Myocarditis remains a common clinical challenge because of its large array of causative
agents and nonspecific presentation. It may result from a common viral infection, and less …