Inflammation and resolution in obesity

M Soták, M Clark, BE Suur, E Börgeson - Nature Reviews …, 2024 - nature.com
Inflammation is an essential physiological defence mechanism, but prolonged or excessive
inflammation can cause disease. Indeed, unresolved systemic and adipose tissue …

Advance computational tools for multiomics data learning

S Mansoor, S Hamid, TT Tuan, JE Park… - Biotechnology Advances, 2024 - Elsevier
The burgeoning field of bioinformatics has seen a surge in computational tools tailored for
omics data analysis driven by the heterogeneous and high-dimensional nature of omics …

Advancing precision medicine: A review of innovative In Silico approaches for drug development, clinical pharmacology and personalized healthcare

L Marques, B Costa, M Pereira, A Silva, J Santos… - Pharmaceutics, 2024 - mdpi.com
The landscape of medical treatments is undergoing a transformative shift. Precision
medicine has ushered in a revolutionary era in healthcare by individualizing diagnostics and …

[HTML][HTML] Integrating Molecular Perspectives: Strategies for Comprehensive Multi-Omics Integrative Data Analysis and Machine Learning Applications in …

PHG Sanches, NC de Melo, AM Porcari… - Biology, 2024 - mdpi.com
Simple Summary Recent high-throughput technologies such as transcriptomics, proteomics,
and metabolomics have allowed progress in understanding biological systems at different …

[HTML][HTML] Proteomics-driven biomarkers in Pancreatic Cancer

L Ramalhete, E Vigia, R Araújo, HP Marques - Proteomes, 2023 - mdpi.com
Pancreatic cancer is a devastating disease that has a grim prognosis, highlighting the need
for improved screening, diagnosis, and treatment strategies. Currently, the sole biomarker …

Computational biology helps understand how polyploid giant cancer cells drive tumor success

MC Casotti, DD Meira, ASS Zetum, BC Araújo… - Genes, 2023 - mdpi.com
Precision and organization govern the cell cycle, ensuring normal proliferation. However,
some cells may undergo abnormal cell divisions (neosis) or variations of mitotic cycles …

[HTML][HTML] Unsupervised Learning in Precision Medicine: Unlocking Personalized Healthcare through AI

A Trezza, A Visibelli, B Roncaglia, O Spiga… - Applied Sciences, 2024 - mdpi.com
Integrating Artificial Intelligence (AI) into Precision Medicine (PM) is redefining healthcare,
enabling personalized treatments tailored to individual patients based on their genetic code …

Innovative Detection of Biomarkers Based on Chemiluminescent Nanoparticles and a Lensless Optical Sensor

C Potrich, G Palmara, F Frascella, L Pancheri, L Lunelli - Biosensors, 2024 - mdpi.com
The identification and quantification of biomarkers with innovative technologies is an urgent
need for the precise diagnosis and follow up of human diseases. Body fluids offer a variety …

AIMedGraph: a comprehensive multi-relational knowledge graph for precision medicine

X Quan, W Cai, C Xi, C Wang, L Yan - Database, 2023 - academic.oup.com
The development of high-throughput molecular testing techniques has enabled the large-
scale exploration of the underlying molecular causes of diseases and the development of …

A multi-omics approach to understand the influence of polyphenols in ovarian cancer for precision nutrition: a mini-review

F Tecchio Borsoi, L Ferreira Alves… - Critical Reviews in …, 2023 - Taylor & Francis
The impact of polyphenols in ovarian cancer is widely studied observing gene expression,
epigenetic alterations, and molecular mechanisms based on new 'omics' technologies …