Solid-state NMR spectroscopy is one of the most commonly used techniques to study the
atomic-resolution structure and dynamics of various chemical, biological, material, and …

Solid-state NMR (ssNMR) spectroscopy analyzes a wide range of pharmaceutical materials
in a non-disruptive and non-invasive manner. The obtained molecular properties at …

Internuclear distances represent one of the main structural constraints in molecular structure
determination using solid-state NMR spectroscopy, complementing chemical shifts and …

Studying disease models at the molecular level is vital for drug development in order to
improve treatment and prevent a wide range of human pathologies. Microbial infections are …

Proton-detected solid-state NMR has emerged as a powerful analytical technique in
structural elucidation via 1H–1H correlations, which are mostly established by broadband …

Fluorinated drugs occupy a large and growing share of the pharmaceutical market. Here, we
explore high-frequency, 60 to 111 kHz, 19F magic-angle spinning (MAS) nuclear magnetic …

Fluorinated compounds are widely used in the fields of molecular imaging, pharmaceuticals,
and materials. Fluorinated natural products in nature are rare, and the introduction of …

Atomic-level characterization of active pharmaceutical ingredients (API) is crucial in
pharmaceutical industry because APIs play an important role in physicochemical properties …

Lorlatinib is an active pharmaceutical ingredient (API) used in the treatment of lung cancer.
Here, an NMR crystallography analysis is presented whereby the single-crystal X-ray …

Despite the wide utilization of amorphous solid dispersions (ASDs) for formulating poorly
water-soluble drugs, fundamental understanding of the structural basis behind their stability …