While human regulatory risk assessment (RA) still largely relies on animal studies, new
approach methodologies (NAMs) based on in vitro, in silico or non-mammalian alternative …

Since the initial development of the exposome concept, much effort has been devoted to the
characterisation of the exposome through analytical, epidemiological, and toxicological …

Abstract The Comparative Toxicogenomics Database (CTD; http://ctdbase. org/) harmonizes
cross-species heterogeneous data for chemical exposures and their biological …

The exposome concept encourages holistic consideration of the non-genetic factors
(environmental exposures including lifestyle) that influence an individual's health over their …

The exposome depicts the total exposures in the lifetime of an organism. Human exposome
comprises exposures from environmental and humanistic sources. Biological, chemical, and …

Anthropogenic activity has created unique environmental drivers, which may interact to
produce unexpected effects. My aim was to conduct a systematic review of the interactive …

The exposome paradigm through an integrated approach to investigating the impact of
perinatal exposure to metals on child neurodevelopment in two cohorts carried out in …

Humans are exposed to a growing list of synthetic chemicals, some of them becoming a
major public health concern due to their capacity to impact multiple biological endpoints and …

Risk assessment methodology, mostly commonly used, faces the complexity of the
environment. Populations are exposed to multiple sources of chemicals throughout life and …

Through investigating the combined impact of the environmental exposures experienced by
an individual throughout their lifetime, exposome research provides opportunities to …