Essential tremor pathology: neurodegeneration and reorganization of neuronal connections
Essential tremor (ET) is the most common tremor disorder globally and is characterized by
kinetic tremor of the upper limbs, although other clinical features can also occur. Postmortem …
kinetic tremor of the upper limbs, although other clinical features can also occur. Postmortem …
Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins
T Herdegen, JD Leah - Brain research reviews, 1998 - Elsevier
This article reviews findings up to the end of 1997 about the inducible transcription factors
(ITFs) c-Jun, JunB, JunD, c-Fos, FosB, Fra-1, Fra-2, Krox-20 (Egr-2) and Krox-24 (NGFI-A …
(ITFs) c-Jun, JunB, JunD, c-Fos, FosB, Fra-1, Fra-2, Krox-20 (Egr-2) and Krox-24 (NGFI-A …
Why is Wallerian degeneration in the CNS so slow?
ME Vargas, BA Barres - Annu. Rev. Neurosci., 2007 - annualreviews.org
Wallerian degeneration (WD) is the set of molecular and cellular events by which
degenerating axons and myelin are cleared after injury. Why WD is rapid and robust in the …
degenerating axons and myelin are cleared after injury. Why WD is rapid and robust in the …
[HTML][HTML] Retinal ganglion cells do not extend axons by default: promotion by neurotrophic signaling and electrical activity
JL Goldberg, JS Espinosa, Y Xu, N Davidson… - Neuron, 2002 - cell.com
We investigate the signaling mechanisms that induce retinal ganglion cell (RGC) axon
elongation by asking whether surviving neurons extend axons by default. We show that bcl …
elongation by asking whether surviving neurons extend axons by default. We show that bcl …
Differential effects of the Rac GTPase on Purkinje cell axons and dendritic trunks and spines
NEURONS contain distinct compartments including dendrites, dendritic spines, axons and
synaptic terminals1. The molecular mechanisms that generate and distinguish these …
synaptic terminals1. The molecular mechanisms that generate and distinguish these …
Bcl-2 promotes regeneration of severed axons in mammalian CNS
DF Chen, GE Schneider, JC Martinou, S Tonegawa - Nature, 1997 - nature.com
Most neurons of the mammalian central nervous system (CNS) lose the ability to regenerate
severed axons in vivo after a certain point in development1. At least part of this loss in …
severed axons in vivo after a certain point in development1. At least part of this loss in …
The relationship between neuronal survival and regeneration
JL Goldberg, BA Barres - Annual review of neuroscience, 2000 - annualreviews.org
The ability of peripheral nervous system (PNS) but not central nervous system (CNS)
neurons to regenerate their axons is a striking peculiarity of higher vertebrates. Much …
neurons to regenerate their axons is a striking peculiarity of higher vertebrates. Much …
Cell-autonomous death of cerebellar purkinje neurons with autophagy in Niemann-Pick type C disease
DC Ko, L Milenkovic, SM Beier, H Manuel… - PLoS …, 2005 - journals.plos.org
Niemann-Pick type C is a neurodegenerative lysosomal storage disorder caused by
mutations in either of two genes, npc1 and npc2. Cells lacking Npc1, which is a …
mutations in either of two genes, npc1 and npc2. Cells lacking Npc1, which is a …
Purkinje cell axonal anatomy: quantifying morphometric changes in essential tremor versus control brains
Growing clinical, neuro-imaging and post-mortem data have implicated the cerebellum as
playing an important role in the pathogenesis of essential tremor. Aside from a modest …
playing an important role in the pathogenesis of essential tremor. Aside from a modest …
Purkinje cell survival and axonal regeneration are age dependent: an in vitro study
Purkinje cells are among the most resistant neurons to axotomy and the most refractory to
axonal regeneration. By using organotypic cultures, we have studied age-and environment …
axonal regeneration. By using organotypic cultures, we have studied age-and environment …