Protein kinase casein kinase 2 (CK2/CSNK2) is a pleiotropic kinase involved in many
cellular processes and, accordingly, has been identified as a potential target for therapeutic …

The human kinome, with more than 500 proteins, is crucial for cell signaling and disease.
Yet, about one-third of kinases lack in-depth study. The Data and Resource Generating …

The pyrazolo [1, 5-a] pyrimidine scaffold is a promising scaffold to develop potent and
selective CSNK2 inhibitors with antiviral activity against β-coronaviruses. Herein, we …

Pathological loss-of-function mutations in cyclin-dependent kinase-like 5 (CDKL5) cause
CDKL5 deficiency disorder (CDD), a rare and severe neurodevelopmental disorder …

CK2 is a vital enzyme that phosphorylates a large number of substrates and thereby controls
many processes in the body. Its upregulation was reported in many cancer types. Inhibitors …

Phenethyl isothiocyanate (PEITC) is a secondary metabolic product yielded upon the
hydrolysis of gluconasturtiin and it is highly accumulated in the flowers of watercress. The …

The host kinase casein kinase 2 (CSNK2) has been proposed to be an antiviral target
against β-coronaviral infection. To pharmacologically validate CSNK2 as a drug target in …

Abstract PIKfyve (1-phosphatidylinositol 3-phosphate 5-kinase), a lipid kinase, plays an
important role in generating phosphatidylinositol (3, 5)-bisphosphate (PI (3, 5) P 2). SGC …

We report the synthesis of 2, 6-disubstituted pyrazines as potent cell active CSNK2A
inhibitors. 4′-Carboxyphenyl was found to be the optimal 2-pyrazine substituent for …

We optimized our highly potent and cell-active chemical probe for phosphatidylinositol-3-
phosphate 5-kinase (PIKfyve), SGC-PIKFYVE-1, resulting in compounds with improved …