[HTML][HTML] Gastrointestinal involvement in Parkinson's disease: pathophysiology, diagnosis, and management
T Warnecke, KH Schäfer, I Claus, K Del Tredici… - npj Parkinson's …, 2022 - nature.com
Growing evidence suggests an increasing significance for the extent of gastrointestinal tract
(GIT) dysfunction in Parkinson's disease (PD). Most patients suffer from GIT symptoms …
(GIT) dysfunction in Parkinson's disease (PD). Most patients suffer from GIT symptoms …
[HTML][HTML] Enteric nervous system: the bridge between the gut microbiota and neurological disorders
ZH Geng, Y Zhu, QL Li, C Zhao… - Frontiers in aging …, 2022 - frontiersin.org
The gastrointestinal (GI) tract plays an essential role in food digestion, absorption, and the
mucosal immune system; it is also inhabited by a huge range of microbes. The GI tract is …
mucosal immune system; it is also inhabited by a huge range of microbes. The GI tract is …
[HTML][HTML] Molecular architecture of the mouse nervous system
A Zeisel, H Hochgerner, P Lönnerberg, A Johnsson… - Cell, 2018 - cell.com
The mammalian nervous system executes complex behaviors controlled by specialized,
precisely positioned, and interacting cell types. Here, we used RNA sequencing of half a …
precisely positioned, and interacting cell types. Here, we used RNA sequencing of half a …
Diversification of molecularly defined myenteric neuron classes revealed by single-cell RNA sequencing
K Morarach, A Mikhailova, V Knoflach, F Memic… - Nature …, 2021 - nature.com
Autonomous regulation of the intestine requires the combined activity of functionally distinct
neurons of the enteric nervous system (ENS). However, the variety of enteric neuron types …
neurons of the enteric nervous system (ENS). However, the variety of enteric neuron types …
[HTML][HTML] Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways
The intestinal epithelium senses nutritional and microbial stimuli using epithelial sensory
enteroendocrine cells (EEC). EECs communicate nutritional information to the nervous …
enteroendocrine cells (EEC). EECs communicate nutritional information to the nervous …
[HTML][HTML] The effect of microbiota and the immune system on the development and organization of the enteric nervous system
Y Obata, V Pachnis - Gastroenterology, 2016 - Elsevier
The gastrointestinal (GI) tract is essential for the absorption of nutrients, induction of mucosal
and systemic immune responses, and maintenance of a healthy gut microbiota. Key aspects …
and systemic immune responses, and maintenance of a healthy gut microbiota. Key aspects …
[HTML][HTML] Enteric nervous system-derived IL-18 orchestrates mucosal barrier immunity
A Jarret, R Jackson, C Duizer, ME Healy, J Zhao… - Cell, 2020 - cell.com
Mucosal barrier immunity is essential for the maintenance of the commensal microflora and
combating invasive bacterial infection. Although immune and epithelial cells are thought to …
combating invasive bacterial infection. Although immune and epithelial cells are thought to …
Enteric nervous system development: what could possibly go wrong?
M Rao, MD Gershon - Nature Reviews Neuroscience, 2018 - nature.com
The gastrointestinal tract contains its own set of intrinsic neuroglial circuits—the enteric
nervous system (ENS)—which detects and responds to diverse signals from the …
nervous system (ENS)—which detects and responds to diverse signals from the …
[HTML][HTML] Enteric neuroimmune interactions coordinate intestinal responses in health and disease
The enteric nervous system (ENS) of the gastrointestinal (GI) tract interacts with the local
immune system bidirectionally. Recent publications have demonstrated that such …
immune system bidirectionally. Recent publications have demonstrated that such …
Neuronal differentiation in Schwann cell lineage underlies postnatal neurogenesis in the enteric nervous system
T Uesaka, M Nagashimada… - Journal of Neuroscience, 2015 - Soc Neuroscience
Elucidation of the cellular identity of neuronal precursors provides mechanistic insights into
the development and pathophysiology of the nervous system. In the enteric nervous system …
the development and pathophysiology of the nervous system. In the enteric nervous system …