Growing evidence suggests an increasing significance for the extent of gastrointestinal tract
(GIT) dysfunction in Parkinson's disease (PD). Most patients suffer from GIT symptoms …

The gastrointestinal (GI) tract plays an essential role in food digestion, absorption, and the
mucosal immune system; it is also inhabited by a huge range of microbes. The GI tract is …

The mammalian nervous system executes complex behaviors controlled by specialized,
precisely positioned, and interacting cell types. Here, we used RNA sequencing of half a …

Autonomous regulation of the intestine requires the combined activity of functionally distinct
neurons of the enteric nervous system (ENS). However, the variety of enteric neuron types …

The intestinal epithelium senses nutritional and microbial stimuli using epithelial sensory
enteroendocrine cells (EEC). EECs communicate nutritional information to the nervous …

The gastrointestinal (GI) tract is essential for the absorption of nutrients, induction of mucosal
and systemic immune responses, and maintenance of a healthy gut microbiota. Key aspects …

Mucosal barrier immunity is essential for the maintenance of the commensal microflora and
combating invasive bacterial infection. Although immune and epithelial cells are thought to …

The gastrointestinal tract contains its own set of intrinsic neuroglial circuits—the enteric
nervous system (ENS)—which detects and responds to diverse signals from the …

The enteric nervous system (ENS) of the gastrointestinal (GI) tract interacts with the local
immune system bidirectionally. Recent publications have demonstrated that such …

Elucidation of the cellular identity of neuronal precursors provides mechanistic insights into
the development and pathophysiology of the nervous system. In the enteric nervous system …