Tuberculosis drug discovery: challenges and new horizons
GFS Fernandes, AM Thompson… - Journal of Medicinal …, 2022 - ACS Publications
Over the past 2000 years, tuberculosis (TB) has claimed more lives than any other infectious
disease. In 2020 alone, TB was responsible for 1.5 million deaths worldwide, comparable to …
disease. In 2020 alone, TB was responsible for 1.5 million deaths worldwide, comparable to …
Cell wall peptidoglycan in Mycobacterium tuberculosis: An Achilles' heel for the TB-causing pathogen
A Maitra, T Munshi, J Healy, LT Martin… - FEMS microbiology …, 2019 - academic.oup.com
Tuberculosis (TB), caused by the intracellular pathogen Mycobacterium tuberculosis,
remains one of the leading causes of mortality across the world. There is an urgent …
remains one of the leading causes of mortality across the world. There is an urgent …
One or two membranes? Diderm Firmicutes challenge the Gram‐positive/Gram‐negative divide
How, when and why the transition between cell envelopes with one membrane (Gram‐
positives or monoderms) and two (Gram‐negative or diderms) occurred in Bacteria is a key …
positives or monoderms) and two (Gram‐negative or diderms) occurred in Bacteria is a key …
Terrabacteria: redefining bacterial envelope diversity, biogenesis and evolution
The bacterial envelope is one of the oldest and most essential cellular components and has
been traditionally divided into Gram-positive (monoderm) and Gram-negative (diderm) …
been traditionally divided into Gram-positive (monoderm) and Gram-negative (diderm) …
Genome-wide analysis of the Firmicutes illuminates the diderm/monoderm transition
The transition between cell envelopes with one membrane (Gram-positive or monoderm)
and those with two membranes (Gram-negative or diderm) is a fundamental open question …
and those with two membranes (Gram-negative or diderm) is a fundamental open question …
Nontuberculous mycobacteria as sapronoses: a review
I Pavlik, V Ulmann, D Hubelova, RT Weston - Microorganisms, 2022 - mdpi.com
Mycobacteria are a unique group of microorganisms. They are characterised by exceptional
adaptability and durability. They are capable of colonisation and survival even in very …
adaptability and durability. They are capable of colonisation and survival even in very …
Geographically dispersed zoonotic tuberculosis in pre-contact South American human populations
Previous ancient DNA research has shown that Mycobacterium pinnipedii, which today
causes tuberculosis (TB) primarily in pinnipeds, infected human populations living in the …
causes tuberculosis (TB) primarily in pinnipeds, infected human populations living in the …
Molecular modeling and simulation of the mycobacterial cell envelope: from individual components to cell envelope assemblies
Unlike typical Gram-positive bacteria, the cell envelope of mycobacteria is unique and
composed of a mycobacterial outer membrane, also known as the mycomembrane, a …
composed of a mycobacterial outer membrane, also known as the mycomembrane, a …
Advances in diagnostics and drug discovery against resistant and latent tuberculosis infection
C Shleider Carnero Canales, J Marquez Cazorla… - Pharmaceutics, 2023 - mdpi.com
Latent tuberculosis infection (LTBI) represents a subclinical, asymptomatic mycobacterial
state affecting approximately 25% of the global population. The substantial prevalence of …
state affecting approximately 25% of the global population. The substantial prevalence of …
Host Cell Targets of Released Lipid and Secreted Protein Effectors of Mycobacterium tuberculosis
J Augenstreich, V Briken - Frontiers in cellular and infection …, 2020 - frontiersin.org
Mycobacterium tuberculosis (Mtb) is a very successful pathogen, strictly adapted to humans
and the cause of tuberculosis. Its success is associated with its ability to inhibit host cell …
and the cause of tuberculosis. Its success is associated with its ability to inhibit host cell …