Bioactive materials are a special class of biomaterials that can react in vivo to induce a
biological response or regulate biological functions, thus achieving a better curative effect …

Nitric oxide (NO), a gaseous transmitter extensively present in the human body, regulates
vascular relaxation, immune response, inflammation, neurotransmission, and other crucial …

Multi-drug resistance (MDR) in cancer cells, either intrinsic or acquired through various
mechanisms, significantly hinders the therapeutic efficacy of drugs. Typically, the reduced …

Nanomedicine, acting as the magic bullet, is capable of combining immunotherapy with
other treatments to reverse a cold tumor (immune depletion) into a hot tumor. However, how …

Nanomaterials with enzyme-like catalytic activity, named as nanozymes, have aroused wide
research interest owing to their striking merits bridging nanotechnology and biology. Metal …

Chemoresistance is a central cause for the tumor management failure. Cancer cells disrupt
the redox homeostasis through reactive oxygen species (ROS) regulatory mechanisms …

Nitric oxide (NO), as an endogenous diatomic molecule, plays a key regulatory role in many
physiological and pathological processes. This diatomic free radical has been shown to …

Gasotransmitters belong to the subfamily of endogenous gaseous signaling molecules,
which find a wide range of biomedical applications. Among the various gasotransmitters …

Photodynamic therapy (PDT) is a promising and emerging method for the treatment of
cancer. Usually, Type II PDT is used in the clinic, and mainly involves three key elements: a …

Chemotherapy for tumors occasionally results in drug resistance, which is the major reason
for the treatment failure. Higher drug doses could improve the therapeutic effect, but higher …