[HTML][HTML] Activation of the EGF receptor by ligand binding and oncogenic mutations: the “rotation model”
ER Purba, E Saita, IN Maruyama - Cells, 2017 - mdpi.com
The epidermal growth factor receptor (EGFR) plays vital roles in cellular processes including
cell proliferation, survival, motility, and differentiation. The dysregulated activation of the …
cell proliferation, survival, motility, and differentiation. The dysregulated activation of the …
[HTML][HTML] Peptide-tags for site-specific protein labelling in vitro and in vivo
J Lotze, U Reinhardt, O Seitz… - Molecular …, 2016 - pubs.rsc.org
Peptide-tags for site-specific protein labelling in vitro and in vivo - Molecular BioSystems (RSC
Publishing) DOI:10.1039/C6MB00023A Royal Society of Chemistry View PDF VersionPrevious …
Publishing) DOI:10.1039/C6MB00023A Royal Society of Chemistry View PDF VersionPrevious …
Photoacoustic molecular imaging: from multiscale biomedical applications towards early-stage theranostics
Photoacoustic imaging (PAI) has ushered in a new era of observational biotechnology and
has facilitated the exploration of fundamental biological mechanisms and clinical …
has facilitated the exploration of fundamental biological mechanisms and clinical …
Epidermal growth factor receptor: Structure-function informing the design of anticancer therapeutics
RA Mitchell, RB Luwor, AW Burgess - Experimental cell research, 2018 - Elsevier
Research on the epidermal growth factor (EGF) family and the family of receptors (EGFR)
has progressed rapidly in recent times. New crystal structures of the ectodomains with …
has progressed rapidly in recent times. New crystal structures of the ectodomains with …
[HTML][HTML] Helix-helix interactions in membrane domains of bitopic proteins: Specificity and role of lipid environment
Interaction between transmembrane helices often determines biological activity of
membrane proteins. Bitopic proteins, a broad subclass of membrane proteins, form dimers …
membrane proteins. Bitopic proteins, a broad subclass of membrane proteins, form dimers …
[HTML][HTML] The epidermal growth factor receptor in healthy pregnancy and preeclampsia
L Clemente, IM Bird - Journal of molecular endocrinology, 2023 - jme.bioscientifica.com
The epidermal growth factor receptor (EGFR) is expressed robustly in the placenta, and
critical processes of pregnancy such as placental growth and trophoblast fusion are …
critical processes of pregnancy such as placental growth and trophoblast fusion are …
Strategies for Site‐Specific Labeling of Receptor Proteins on the Surfaces of Living Cells by Using Genetically Encoded Peptide Tags
P Wolf, G Gavins, AG Beck‐Sickinger, O Seitz - ChemBioChem, 2021 - Wiley Online Library
Fluorescence microscopy imaging enables receptor proteins to be investigated within their
biological context. A key challenge is to site‐specifically incorporate reporter moieties into …
biological context. A key challenge is to site‐specifically incorporate reporter moieties into …
[HTML][HTML] The dependence of EGFR oligomerization on environment and structure: A camera-based N&B study
Abstract Number and brightness (N&B) analysis is a fluorescence spectroscopy technique to
quantify oligomerization of the mobile fraction of proteins. Accurate results, however, rely on …
quantify oligomerization of the mobile fraction of proteins. Accurate results, however, rely on …
Strand displacement in coiled‐coil structures: Controlled induction and reversal of proximity
K Gröger, G Gavins, O Seitz - Angewandte Chemie, 2017 - Wiley Online Library
Coiled‐coil peptides are frequently used to create new function upon the self‐assembly of
supramolecular complexes. A multitude of coil peptide sequences provides control over the …
supramolecular complexes. A multitude of coil peptide sequences provides control over the …
[HTML][HTML] Using an RNA aptamer probe for super-resolution imaging of native EGFR
Q Yan, M Cai, L Zhou, H Xu, Y Shi, J Sun, J Jiang… - Nanoscale …, 2019 - pubs.rsc.org
Aptamers, referred to as “chemical antibodies”, are short single-stranded oligonucleotides
that bind to targets with high affinity and specificity. Compared with antibodies, aptamers can …
that bind to targets with high affinity and specificity. Compared with antibodies, aptamers can …