Since the discovery of the phosphorylation of the 40S ribosomal protein S6 (rpS6) about four
decades ago, much effort has been made to uncover the molecular mechanisms underlying …

A major goal of current research in schizophrenia is to understand the biology underlying
onset and early progression and to develop interventions that modify these processes …

Pregnancy is marked by robust changes, including brain changes to volume, structure,
connectivity and neuroplasticity. Although some brain changes are restricted to pregnancy …

AKT is a kinase regulating numerous cellular processes in the brain, and mutations in AKT
are known to affect brain function. AKT is indirectly implicated in synaptic plasticity, but its …

Human olfactory neurosphere-derived (ONS) cells have the potential to provide novel
insights into the cellular pathology of schizophrenia. We used discovery-based proteomics …

The AKT-mTOR signaling transduction pathway plays an important role in
neurodevelopment and synaptic plasticity. mTOR is a serine/threonine kinase that …

Altered transcription of calcium-dependent signaling cascades involving the ryanodine
receptor (RyR) and mechanistic target of rapamycin (mTOR) in response to environmental …

Genomic studies have repeatedly associated variants in the gene encoding the microRNA
miR-137 with increased schizophrenia risk. Bioinformatic predictions suggest that miR-137 …

Microglial cells are resident macrophages in the brain that have been implicated in the
pathophysiology of schizophrenia. There is a lack of studies covering the effects of …

Regulation of gene expression at the level of protein synthesis is a crucial element in driving
how the genetic landscape is expressed. However, we are still limited in technologies that …