Role of the mitochondrial protein import machinery and protein processing in heart disease
Mitochondria are essential organelles for cellular energy production, metabolic
homeostasis, calcium homeostasis, cell proliferation, and apoptosis. About 99% of …
homeostasis, calcium homeostasis, cell proliferation, and apoptosis. About 99% of …
Alpha crystallins in the retinal pigment epithelium and implications for the pathogenesis and treatment of age-related macular degeneration
Background αA-and αB crystallins are principal members of the small heat shock protein
family and elicit both a cell protective function and a chaperone function. α-Crystallins have …
family and elicit both a cell protective function and a chaperone function. α-Crystallins have …
Role of α-crystallin B as a regulatory switch in modulating cardiomyocyte apoptosis by mitochondria or endoplasmic reticulum during cardiac hypertrophy and …
Cardiac hypertrophy and myocardial infarction (MI) are two major causes of heart failure with
different etiologies. However, the molecular mechanisms associated with these two …
different etiologies. However, the molecular mechanisms associated with these two …
[HTML][HTML] Senolysis induced by 25-hydroxycholesterol targets CRYAB in multiple cell types
Cellular senescence is a driver of many age-related pathologies. There is an active search
for pharmaceuticals termed senolytics that can mitigate or remove senescent cells in vivo by …
for pharmaceuticals termed senolytics that can mitigate or remove senescent cells in vivo by …
Hypoxia-induced changes in the fibroblast secretome, exosome, and whole-cell proteome using cultured, cardiac-derived cells isolated from neonatal mice
Cardiac fibroblasts (CFs) represent a major subpopulation of cells in the developing and
adult heart. Cardiomyocyte (CM) and CF intercellular communication occurs through …
adult heart. Cardiomyocyte (CM) and CF intercellular communication occurs through …
miR‐181a and miR‐150 regulate dendritic cell immune inflammatory responses and cardiomyocyte apoptosis via targeting JAK1–STAT1/c‐Fos pathway
J Zhu, K Yao, J Guo, H Shi, L Ma… - Journal of cellular …, 2017 - Wiley Online Library
The immune inflammatory response plays a crucial role in many cardiac pathophysiological
processes, including ischaemic cardiac injury and the post‐infarction repair process. Micro …
processes, including ischaemic cardiac injury and the post‐infarction repair process. Micro …
Alpha B-crystallin in muscle disease prevention: the role of physical activity
I Dimauro, D Caporossi - Molecules, 2022 - mdpi.com
HSPB5 or alpha B-crystallin (CRYAB), originally identified as lens protein, is one of the most
widespread and represented of the human small heat shock proteins (sHSPs). It is greatly …
widespread and represented of the human small heat shock proteins (sHSPs). It is greatly …
Cell biological roles of αB-crystallin
WC Boelens - Progress in biophysics and molecular biology, 2014 - Elsevier
Abstract αB-crystallin, also called HspB5, is a molecular chaperone able to interact with
unfolding proteins. By interacting, it inhibits further unfolding, thereby preventing protein …
unfolding proteins. By interacting, it inhibits further unfolding, thereby preventing protein …
Desmin and its molecular chaperone, the αB-crystallin: How post-translational modifications modulate their functions in heart and skeletal muscles?
C Claeyssen, N Bulangalire, B Bastide, O Agbulut… - Biochimie, 2023 - Elsevier
Maintenance of the highly organized striated muscle tissue requires a cell-wide dynamic
network through protein-protein interactions providing an effective mechanochemical …
network through protein-protein interactions providing an effective mechanochemical …
BYD ameliorates oxidative stress-induced myocardial apoptosis in heart failure post-acute myocardial infarction via the P38 MAPK-CRYAB signaling pathway
Y Zhang, C Li, H Meng, D Guo, Q Zhang, W Lu… - Frontiers in …, 2018 - frontiersin.org
Aim: Heart failure (HF) post-acute myocardial infarction (AMI) contributes to increasing
mortality and morbidity worldwide. Baoyuan decoction (BYD) is a well-known traditional …
mortality and morbidity worldwide. Baoyuan decoction (BYD) is a well-known traditional …