Ecology and evolution of Mycobacterium tuberculosis

S Gagneux - Nature Reviews Microbiology, 2018 - nature.com
Tuberculosis (TB) is the number one cause of human death due to an infectious disease.
The causative agents of TB are a group of closely related bacteria known as the …

Co‐evolution of Mycobacterium tuberculosis and Homo sapiens

D Brites, S Gagneux - Immunological reviews, 2015 - Wiley Online Library
The causative agent of human tuberculosis (TB), M ycobacterium tuberculosis, is an obligate
pathogen that evolved to exclusively persist in human populations. For M. tuberculosis to …

Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages

D Stucki, D Brites, L Jeljeli, M Coscolla, Q Liu… - Nature …, 2016 - nature.com
Generalist and specialist species differ in the breadth of their ecological niches. Little is
known about the niche width of obligate human pathogens. Here we analyzed a global …

Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis

KI Bos, KM Harkins, A Herbig, M Coscolla, N Weber… - Nature, 2014 - nature.com
Modern strains of Mycobacterium tuberculosis from the Americas are closely related to those
from Europe, supporting the assumption that human tuberculosis was introduced post …

Frequent transmission of the Mycobacterium tuberculosis Beijing lineage and positive selection for the EsxW Beijing variant in Vietnam

KE Holt, P McAdam, PVK Thai, NTT Thuong, DTM Ha… - Nature …, 2018 - nature.com
To examine the transmission dynamics of Mycobacterium tuberculosis (Mtb) isolated from
tuberculosis patients in Ho Chi Minh City, Vietnam, we sequenced the whole genomes of …

[HTML][HTML] Genomic insights into tuberculosis

JE Galagan - Nature Reviews Genetics, 2014 - nature.com
Prevalent since pre-history, human tuberculosis—caused by the pathogen Mycobacterium
tuberculosis—remains a major source of death worldwide. Moreover, increasing drug …

[HTML][HTML] The molecular clock of Mycobacterium tuberculosis

F Menardo, S Duchêne, D Brites, S Gagneux - PLoS pathogens, 2019 - journals.plos.org
The molecular clock and its phylogenetic applications to genomic data have changed how
we study and understand one of the major human pathogens, Mycobacterium tuberculosis …

Methodological and clinical aspects of the molecular epidemiology of Mycobacterium tuberculosis and other mycobacteria

T Jagielski, A Minias, J van Ingen… - Clinical microbiology …, 2016 - Am Soc Microbiol
Molecular typing has revolutionized epidemiological studies of infectious diseases,
including those of a mycobacterial etiology. With the advent of fingerprinting techniques …

[HTML][HTML] An ancestral mycobacterial effector promotes dissemination of infection

JW Saelens, MI Sweeney, G Viswanathan, AM Xet-Mull… - Cell, 2022 - cell.com
The human pathogen Mycobacterium tuberculosis typically causes lung disease but can
also disseminate to other tissues. We identified a M. tuberculosis (Mtb) outbreak presenting …

Overview and phylogeny of Mycobacterium tuberculosis complex organisms: implications for diagnostics and legislation of bovine tuberculosis

S Rodriguez-Campos, NH Smith, MB Boniotti… - Research in veterinary …, 2014 - Elsevier
Members of the Mycobacterium tuberculosis complex (MTBC) cause a serious disease with
similar pathology, tuberculosis; in this review, bovine tuberculosis will be considered as …