Abstract Nuclear Factor-Erythroid Factor 2 (Nrf2) is an important transcription factor that
regulates the expression of large number of genes in healthy and disease states. Nrf2 is …

Increased reactive oxygen species production and oxidative stress have been implicated in
the pathogenesis of numerous neurodegenerative conditions including among others …

Autophagy is a highly conserved lysosomal degradation pathway active at basal levels in all
cells. However, under stress conditions, such as a lack of nutrients or trophic factors, it works …

Living cells continually generate reactive oxygen species (ROS) through the respiratory
chain during energetic metabolism. ROS at low or moderate concentration can play …

Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat
expansion in the gene encoding for huntingtin protein. A lot has been learned about this …

Aging is an inherently complex process that is manifested within an organism at genetic,
molecular, cellular, organ, and system levels. Although the fundamental mechanisms are …

There is increasing awareness of the ubiquitous role of oxidative stress in
neurodegenerative disease states. A continuing challenge is to be able to distinguish …

Rising interest in the mechanism and function of the proteasomes and the ubiquitin system
revealed that it is hard to find any aspect of the cellular metabolic network that is not directly …

Neurodegenerative diseases share various pathological features, such as accumulation of
aberrant protein aggregates, microglial activation, and mitochondrial dysfunction. These …

In recent years, it has become increasingly clear that mitochondrial dysfunction and
oxidative damage are major contributors to neuronal loss. Free radicals, typically generated …