Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs

G Cirino, C Szabo… - Physiological …, 2023 - journals.physiology.org
Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …

Chemical Biology of H2S Signaling through Persulfidation

MR Filipovic, J Zivanovic, B Alvarez… - Chemical …, 2018 - ACS Publications
Signaling by H2S is proposed to occur via persulfidation, a posttranslational modification of
cysteine residues (RSH) to persulfides (RSSH). Persulfidation provides a framework for …

A review of hydrogen sulfide synthesis, metabolism, and measurement: is modulation of hydrogen sulfide a novel therapeutic for cancer?

X Cao, L Ding, Z Xie, Y Yang, M Whiteman… - Antioxidants & redox …, 2019 - liebertpub.com
Abstract Significance: Hydrogen sulfide (H2S) has been recognized as the third gaseous
transmitter alongside nitric oxide and carbon monoxide. In the past decade, numerous …

International union of basic and clinical pharmacology. CII: pharmacological modulation of H2S levels: H2S donors and H2S biosynthesis inhibitors

C Szabo, A Papapetropoulos, EH Ohlstein - Pharmacological reviews, 2017 - Elsevier
Over the last decade, hydrogen sulfide (H 2 S) has emerged as an important endogenous
gasotransmitter in mammalian cells and tissues. Similar to the previously characterized …

Environmental toxicology of hydrogen sulfide

SLM Rubright, LL Pearce, J Peterson - Nitric Oxide, 2017 - Elsevier
The passenger-carrying paddle steamer Princess Alice was sunk in a collision on the River
Thames in 1878 with the loss of over 640 lives and, curiously, may represent one of the …

A timeline of hydrogen sulfide (H2S) research: From environmental toxin to biological mediator

C Szabo - Biochemical pharmacology, 2018 - Elsevier
The history of H 2 S–as an environmental toxin–dates back to 1700, to the observations of
the Italian physician Bernardino Ramazzini, whose book “De Morbis Artificum Diatriba” …

The role of hydrogen sulfide in evolution and the evolution of hydrogen sulfide in metabolism and signaling

KR Olson, KD Straub - Physiology, 2016 - journals.physiology.org
The chemical versatility of sulfur and its abundance in the prebiotic Earth as reduced sulfide
(H2S) implicate this molecule in the origin of life 3.8 billion years ago and also as a major …

Identification of H2S3 and H2S produced by 3-mercaptopyruvate sulfurtransferase in the brain

Y Kimura, Y Toyofuku, S Koike, N Shibuya… - Scientific reports, 2015 - nature.com
Hydrogen polysulfides (H2Sn) have a higher number of sulfane sulfur atoms than hydrogen
sulfide (H2S), which has various physiological roles. We recently found H2Sn in the brain …

Persulfidation (S-sulfhydration) and H2S

MR Filipovic - … , biochemistry and pharmacology of hydrogen sulfide, 2015 - Springer
The past decade has witnessed the discovery of hydrogen sulfide (H 2 S) as a new
signalling molecule. Its ability to act as a neurotransmitter, regulator of blood pressure …

Metabolism of hydrogen sulfide (H2S) and production of reactive sulfur species (RSS) by superoxide dismutase

KR Olson, Y Gao, F Arif, K Arora, S Patel, ER DeLeon… - Redox Biology, 2018 - Elsevier
Reactive sulfur species (RSS) such as H 2 S, HS•, H 2 S n,(n= 2–7) and HS 2•-are
chemically similar to H 2 O and the reactive oxygen species (ROS) HO•, H 2 O 2, O 2•-and …