Spinal muscular atrophy (SMA) is a devastating childhood motor neuron disease that, in the
most severe cases and when left untreated, leads to death within the first two years of life …

MicroRNAs (miRNAs) are a key gene regulator and play essential roles in several biological
and pathological mechanisms in the human system. In recent years, plenty of miRNAs have …

Amyotrophic lateral sclerosis (ALS) is a fatal, neurodegenerative condition characterized by
loss of motor neurones and progressive muscle wasting. There is no diagnostic test for ALS …

In response to environmental cues, enzymes that influence the functions of proteins, through
reversible post-translational modifications supervise the coordination of cell behavior like …

Controlling access to genomic information and maintaining its stability are key aspects of
cell life. Histone acetylation is a reversible epigenetic modification that allows access to DNA …

Exploring the microRNAs and aptamers for their therapeutic role as biological drugs has
expanded the horizon of its applicability against various human diseases, explicitly targeting …

Neurodegenerative diseases (NDDs) are the result of progressive deterioration of neurons,
ultimately leading to disabilities. There is no effective cure for NDDs at present; ongoing …

Spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative disease
characterized by the selective death of lower motor neurons in the brain stem and spinal …

Spinal muscular atrophy (SMA) is the most common genetic disease affecting infants and
young adults. Due to mutation/deletion of the survival motor neuron (SMN) gene, SMA is …

Few studies have explored the role of microRNAs (or miRNAs) in Amyotrophic Lateral
Sclerosis (ALS) muscle, possibly because of the difficulty in obtaining samples and because …