Recent advances in interrogating RNA folding dynamics have shown the classical model of
RNA folding to be incomplete. Here, we pose three prominent questions for the field that are …

The expression of genes, both coding and noncoding, can be significantly influenced by
RNA structural features of their corresponding transcripts. There is by now mounting …

The series of RNA folding events that occur during transcription can critically influence
cellular RNA function. Here, we present reconstructing RNA dynamics from data (R2D2), a …

Macromolecular function commonly involves rapidly reversible alterations in three-
dimensional structure (conformation). To allow these essential conformational changes …

Viroids were described 47 years ago as the smallest RNA molecules capable of infecting
plants and autonomously self-replicating without an encoded protein. Work on viroids …

RNAs, which play significant roles in many fundamental biological processes of life, fold into
sophisticated and precise structures. RNA folding is a dynamic and intricate process, which …

Temperature is one of the decisive signals that a mammalian pathogen has entered its warm-
blooded host. Among the many ways to register temperature changes, bacteria often use …

Background The design of multi-stable RNA molecules has important applications in
biology, medicine, and biotechnology. Synthetic design approaches profit strongly from …

Background RNA secondary structures play a pivotal role in posttranscriptional regulation
and the functions of non‐coding RNAs, yet in vivo RNA secondary structures remain …

Bacterial pathogens encounter several different environments during an infection, many of
them possibly being detrimental. In order to sense its surroundings and adjust the gene …