Advances in RNA 3D structure modeling using experimental data
RNA is a unique bio-macromolecule that can both record genetic information and perform
biological functions in a variety of molecular processes, including transcription, splicing …
biological functions in a variety of molecular processes, including transcription, splicing …
Improved gRNA secondary structures allow editing of target sites resistant to CRISPR-Cas9 cleavage
S Riesenberg, N Helmbrecht, P Kanis, T Maricic… - Nature …, 2022 - nature.com
The first step in CRISPR-Cas9-mediated genome editing is the cleavage of target DNA
sequences that are complementary to so-called spacer sequences in CRISPR guide RNAs …
sequences that are complementary to so-called spacer sequences in CRISPR guide RNAs …
Molecular structure, binding affinity, and biological activity in the epigenome
Development of valid structure–activity relationships (SARs) is a key to the elucidation of
pathomechanisms of epigenetic diseases and the development of efficient, new drugs. The …
pathomechanisms of epigenetic diseases and the development of efficient, new drugs. The …
Break to Build: Isothermal Assembly of Nucleic Acid Nanoparticles (NANPs) via Enzymatic Degradation
The intrinsic properties of RNA and DNA biopolymers emphasized by engineered nucleic
acid nanoparticles (NANPs) offer accelerated development of next-generation therapies …
acid nanoparticles (NANPs) offer accelerated development of next-generation therapies …
An NMR-based approach reveals the core structure of the functional domain of SINEUP lncRNAs
T Ohyama, H Takahashi, H Sharma… - Nucleic Acids …, 2020 - academic.oup.com
Long non-coding RNAs (lncRNAs) are attracting widespread attention for their emerging
regulatory, transcriptional, epigenetic, structural and various other functions. Comprehensive …
regulatory, transcriptional, epigenetic, structural and various other functions. Comprehensive …
Turn-on RNA Mango Beacons for trans-acting fluorogenic nucleic acid detection
A Abdolahzadeh, QR Ang, JR Caine… - RNA, 2024 - rnajournal.cshlp.org
The Mango I and II RNA aptamers have been widely used in vivo and in vitro as genetically
encodable fluorogenic markers that undergo large increases in fluorescence upon binding …
encodable fluorogenic markers that undergo large increases in fluorescence upon binding …
Combining Experimental Restraints and RNA 3D Structure Prediction in RNA Nanotechnology
Precise RNA tertiary structure prediction can aid in the design of RNA nanoparticles.
However, most existing RNA tertiary structure prediction methods are limited to small RNAs …
However, most existing RNA tertiary structure prediction methods are limited to small RNAs …
Detection of pks Island mRNAs Using Toehold Sensors in Escherichia coli
Synthetic biologists have applied biomolecular engineering approaches toward the goal of
novel biological devices and have shown progress in diverse areas of medicine and …
novel biological devices and have shown progress in diverse areas of medicine and …
Application of rna tertiary structure prediction tool ifoldrna in rna nanotechnology
J Wang, NV Dokholyan - RNA Nanotechnology and Therapeutics, 2022 - taylorfrancis.com
The various activities of RNAs are dictated by their specific tertiary structures; thus the
knowledge of RNA tertiary structure is elementary for understanding RNA functions. After …
knowledge of RNA tertiary structure is elementary for understanding RNA functions. After …
[HTML][HTML] Whole proteome mapping of compound-protein interactions
Off-target binding is one of the primary causes of toxic side effects of drugs in clinical
development, resulting in failures of clinical trials. While off-target drug binding is a known …
development, resulting in failures of clinical trials. While off-target drug binding is a known …