In the past 10 years, microbiology has undergone a revolution that has been driven by
access to cheap high-throughput DNA sequencing. It was not long ago that the cloning and …

Thyroglobulin (Tg) is a vertebrate secretory protein synthesized in the thyrocyte endoplasmic
reticulum (ER), where it acquires N-linked glycosylation and conformational maturation …

The parasite Plasmodium falciparum is responsible for hundreds of millions of cases of
malaria, and kills more than one million African children annually. Here we report an …

The completion of the genome sequence for Plasmodium falciparum, the species
responsible for most malaria human deaths, has the potential to reveal hundreds of new …

Cytoadhesion of infected red blood cells (iRBC) is mediated through parasite‐encoded,
clonally variant surface antigens (VSA) and is a central process in the pathogenesis of …

Clonally variant gene families underlie phenotypic plasticity in Plasmodium falciparum, a
process indispensable for survival of the pathogen in its human host. Differential …

Motivation: The accuracy of reference genomes is important for downstream analysis but a
low error rate requires expensive manual interrogation of the sequence. Here, we describe a …

The life cycle of the parasite Plasmodium falciparum, responsible for the most deadly form of
human malaria, requires specialized protein expression for survival in the mammalian host …

Identification of novel targets for the development of more effective antimalarial drugs and
vaccines is a primary goal of the Plasmodium genome project. However, deciding which …

A map of protein–protein interactions provides valuable insight into the cellular function and
machinery of a proteome. By measuring the similarity between two Gene Ontology (GO) …