Polypharmacology describes the activity of compounds at multiple targets. Current research
focuses on two aspects of polypharmacology:(1) unintended polypharmacology can lead to …

Despite its history as a human teratogen, thalidomide is emerging as a treatment for cancer
and inflammatory diseases. Although the evolution of its clinical application could not have …

The widely accepted standard therapy for cutaneous sarcoidosis includes corticosteroids,
antimalarials, and methotrexate. However, a better understanding of the basic …

Thalidomide is a drug with interesting therapeutic properties but also with severe side effects
which require a careful and monitored use. Potential immunomodulatory, antiinflammatory …

Although healthcare providers have arrived at a relatively comfortable zone of accepted
clinical practice in the management of cutaneous sarcoidosis, virtually every treatment is …

OBJECTIVE: This study was designed to evaluate the anti-angiogenic effect of silymarin
(SM) and its major pure component silibinin (SB), and also thalidomide (TH). MATERIALS …

Neurosarcoidosis can be 'staged'with the use of neurodiagnostic testing and diagnosed with
varying degrees of certainty. Treatment should be approached within the context of the …

The binding of small molecules to double stranded DNA including intercalation between
base pairs has been a topic of research for over 40 years. For the most part, however …

Despite its controversial past, thalidomide is currently under investigation for the treatment of
several disease types, ranging from inflammatory conditions to cancer. The mechanism of …

Keloids are characterized by the vigorously continuous production of extracellular matrix
protein and aberrant cytokine activity in the dermis. There is a growing body of evidence that …