Both G protein-coupled receptors (GPCRs) and receptor-tyrosine kinases (RTKs) regulate
large signaling networks, control multiple cell functions and are implicated in many diseases …

The major clinical associations with the progression of diabetic kidney disease (DKD) are
glycemic control and systemic hypertension. Recent studies have continued to emphasize …

Urotensin II (UII) is a cyclic neuropeptide that was first isolated from the urophysis of teleost
fish on the basis of its ability to contract the hindgut. Subsequently, UII was characterized in …

Abstract Aims Angiotensin II (Ang II) causes vascular inflammation, leading to vascular
endothelial cell dysfunction, and is associated with the development of cardiovascular …

Cardiac, skeletal, and smooth muscle cells shared the common feature of contraction in
response to different stimuli. Agonist-induced muscle's contraction is triggered by a cytosolic …

Abstract Transient Receptor Potential (TRP) channel proteins are a diverse family of proteins
that are expressed in many organisms, tissues and cell types. TRP channels respond to a …

Store-operated channels (SOCs) are highly selective Ca2+ channels that mediate Ca2+
influx in non-excitable and excitable (ie, skeletal and cardiac muscle) cells. These channels …

Transient receptor potential canonical (TRPC) channels are the most prominent
nonselective cation channels involved in various diseases. However, the function, clinical …

Voltage-gated L-type Ca2+ channel (Cav1. 2) blockers (LCCBs) are major drugs for treating
hypertension, the preeminent risk factor for heart failure. Vascular smooth muscle cell …

Objective—To determine the role of orai1 store–operated Ca2+ entry in foam cell formation
and atherogenesis. Approach and Results—Acute administration of oxidized low-density …