Candida auris Genetics and Emergence

A Chowdhary, K Jain, N Chauhan - Annual Review of …, 2023 - annualreviews.org
Candida auris is a multidrug-resistant fungal pathogen that presents a serious threat to
global human health. Since the first reported case in 2009 in Japan, C. auris infections have …

Drug resistance and tolerance in fungi

J Berman, DJ Krysan - Nature Reviews Microbiology, 2020 - nature.com
Systemic fungal infections pose a serious clinical problem. Treatment options are limited,
and antifungal drug resistance is increasing. In addition, a substantial proportion of patients …

Breakthrough invasive fungal infections: Who is at risk?

JD Jenks, OA Cornely, SCA Chen, GR Thompson III… - Mycoses, 2020 - Wiley Online Library
The epidemiology of invasive fungal infections (IFIs) in immunocompromised individuals has
changed over the last few decades, partially due to the increased use of antifungal agents to …

Fungal cell wall: emerging antifungals and drug resistance

SL Lima, AL Colombo… - Frontiers in microbiology, 2019 - frontiersin.org
The cell wall is an essential component in fungal homeostasis. The lack of a covering wall in
human cells makes this component an attractive target for antifungal development. The host …

Candida albicans Antifungal Resistance and Tolerance in Bloodstream Infections: The Triad Yeast-Host-Antifungal

S Costa-de-Oliveira, AG Rodrigues - Microorganisms, 2020 - mdpi.com
Candida albicans represents the most frequent isolated yeast from bloodstream infections.
Despite the remarkable progress in diagnostic and therapeutic approaches, these infections …

Defining breakthrough invasive fungal infection–Position paper of the mycoses study group education and research consortium and the European Confederation of …

OA Cornely, M Hoenigl, C Lass‐Flörl, SCA Chen… - Mycoses, 2019 - Wiley Online Library
Breakthrough invasive fungal infections (IFI s) have emerged as a significant problem in
patients receiving systemic antifungals; however, consensus criteria for defining …

[HTML][HTML] Drug resistance and novel therapeutic approaches in invasive candidiasis

SE Murphy, T Bicanic - Frontiers in cellular and infection microbiology, 2021 - frontiersin.org
Candida species are the leading cause of invasive fungal infections worldwide and are
associated with acute mortality rates of~ 50%. Mortality rates are further augmented in the …

A comprehensive overview of the medicinal chemistry of antifungal drugs: perspectives and promise

KC Howard, EK Dennis, DS Watt… - Chemical Society …, 2020 - pubs.rsc.org
The emergence of new fungal pathogens makes the development of new antifungal drugs a
medical imperative that in recent years motivates the talents of numerous investigators …

[HTML][HTML] Facilitators of adaptation and antifungal resistance mechanisms in clinically relevant fungi

MWJ Hokken, BJ Zwaan, WJG Melchers… - Fungal genetics and …, 2019 - Elsevier
Opportunistic fungal pathogens can cause a diverse range of diseases in humans. The
increasing rate of fungal infections caused by strains that are resistant to commonly used …

Candida parapsilosis sensu stricto Antifungal Resistance Mechanisms and Associated Epidemiology

I Franconi, C Rizzato, N Poma, A Tavanti, A Lupetti - Journal of Fungi, 2023 - mdpi.com
Fungal diseases cause millions of deaths per year worldwide. Antifungal resistance has
become a matter of great concern in public health. In recent years rates of non-albicans …