Social scientists have long understood race to be a social category invented to justify slavery
and evolutionary biologists know the socially constructed racial categories do not align with …

Introduction Hypocholesterolemia results from genetic–both monogenic and polygenic–and
non-genetic causes and can sometimes be a source of clinical concern. We review …

Provided herein are systems, compositions, and methods of introducing loss-of-function
mutations in to protein factors involved in the LDL-R-mediated cholesterol clearance …

Background: Loss-of-function mutations in the LDL (low-density lipoprotein) receptor gene
(LDLR) cause elevated levels of LDL cholesterol and premature cardiovascular disease. To …

The evolution of island populations in natural systems is driven by local adaptation and
genetic drift. However, evolutionary pathways may be altered by humans in several ways …

Background Familial hypercholesterolemia (FH) is caused by pathogenic variants in low-
density lipoprotein (LDL) receptor (LDLR) or its associated genes, including apolipoprotein …

Background Dyslipidemia, a significant risk factor for atherosclerotic cardiovascular disease
(ASCVD), is influenced by genetic variations, particularly those in the low-density lipoprotein …

Background Familial hypercholesterolemia (FH) is an autosomal dominant disorder
characterized by increased LDL-cholesterol levels. About 85% of FH cases are caused by …

Background: Hypercholesterolemia is a complex trait, resulting from a genetic interaction
with lifestyle habits. Polymorphisms are a major source of genetic heterogeneity, and …

Fibrinogen and its functional aspects have been linked to cardiovascular disease. There is
vast discrepancy between the heritability of fibrinogen concentrations observed in twin …