BACKGROUND Early reproductive failure is the most common complication of pregnancy
with only 30% of conceptions reaching live birth. Establishing a successful pregnancy …

The placenta is the chief regulator of nutrient supply to the growing embryo during gestation.
As such, adequate placental function is instrumental for developmental progression …

The human embryo undergoes morphogenetic transformations following implantation into
the uterus, but our knowledge of this crucial stage is limited by the inability to observe the …

Background Embryo selection with preimplantation genetic testing for aneuploidy (PGT-A)
may improve pregnancy outcomes after initial embryo transfer. However, it remains …

Chromosomal instability leading to aneuploidy is pervasive in early human embryos,–and is
considered as a major cause of infertility and pregnancy wastage,. Here we provide several …

Decidualization denotes the transformation of endometrial stromal fibroblasts into
specialized secretory decidual cells that provide a nutritive and immunoprivileged matrix …

The high incidence of aneuploidy in the embryo is considered the principal cause for low
human fecundity. However, the prevalence of aneuploidy dramatically declines as …

Most human pre-implantation embryos are mosaics of euploid and aneuploid cells. To
determine the fate of aneuploid cells and the developmental potential of mosaic embryos …

Periconceptional diet may persistently influence DNA methylation levels with phenotypic
consequences. However, a comprehensive assessment of the characteristics of prenatal …

Following implantation, the human embryo undergoes major morphogenetic transformations
that establish the future body plan. While the molecular events underpinning this process …