BACKGROUND Early reproductive failure is the most common complication of pregnancy
with only 30% of conceptions reaching live birth. Establishing a successful pregnancy …

The placenta is the chief regulator of nutrient supply to the growing embryo during gestation.
As such, adequate placental function is instrumental for developmental progression …

The human embryo undergoes morphogenetic transformations following implantation into
the uterus, but our knowledge of this crucial stage is limited by the inability to observe the …

Background Embryo selection with preimplantation genetic testing for aneuploidy (PGT-A)
may improve pregnancy outcomes after initial embryo transfer. However, it remains …

Decidualization denotes the transformation of endometrial stromal fibroblasts into
specialized secretory decidual cells that provide a nutritive and immunoprivileged matrix …

Chromosomal instability leading to aneuploidy is pervasive in early human embryos,–and is
considered as a major cause of infertility and pregnancy wastage,. Here we provide several …

Most human pre-implantation embryos are mosaics of euploid and aneuploid cells. To
determine the fate of aneuploid cells and the developmental potential of mosaic embryos …

Periconceptional diet may persistently influence DNA methylation levels with phenotypic
consequences. However, a comprehensive assessment of the characteristics of prenatal …

Sporadic miscarriage is the most common complication of early pregnancy. Two or three
consecutive pregnancy losses is a less common phenomenon, and this is considered a …

STUDY QUESTION Are there correlations among human blastocyst ploidy status, standard
morphology evaluation and time-lapse kinetics? SUMMARY ANSWER Correlations were …