In the past 65 years, antifolates targeting folate metabolism played a pivotal role in drug
treatment of malignant, microbial, parasitic and chronic inflammatory diseases. Drug …

THE ESSENTIAL role of intracellular folates in effecting one-carbon transfers in critical
enzyme systems for DNA synthesis is well established. 1., 2., 3. This has led to extensive …

Folates play a key role in one-carbon metabolism essential for the biosynthesis of purines,
thymidylate and hence DNA replication. The antifolate methotrexate has been rationally …

MicroRNAs are predicted to regulate≈ 30% of all human genes by targeting sequences in
their 3′ UTR. Polymorphisms in 3′ UTR of several genes have been reported to affect …

The classical antifolate N-{4-[(2, 4-diamino-5-ethyl-7 H-pyrrolo [2, 3-d] pyrimidin-6-yl)
sulfanyl] benzoyl}-l-glutamic acid (2) and 15 nonclassical analogues (3− 17) were …

The vitamin folic acid was initially investigated as a dietary antianemia factor distinct from the
pernicious anemia factor [1] and a recent historical review details early studies on the …

The antifolates were the first class of antimetabolites to enter the clinics more than 50 years
ago. Over the following decades, a full understanding of their mechanisms of action and …

During the fifteen years since the bestselling first edition of Folate in Health and Disease
was published, there have been thousands of new research studies related to folate and its …

We have recently determined that human multidrug resistance protein (MRP) 3, which
confers resistance to certain natural product agents and methotrexate (MTX), is competent in …

Members of the ATP-binding cassette (ABC) transporters including P-glycoprotein
(Pgp/ABCB1), multidrug resistance proteins (MRPs/ABCC) as well as breast cancer …