Animal behavior is shaped by a variety of" internal states"—partially hidden variables that
profoundly shape perception, cognition, and action. The neural basis of internal states, such …

Obesity is among the most common and costly chronic disorders worldwide. Estimates
suggest that in the United States obesity affects one-third of adults, accounts for up to one …

The nervous and immune systems are intricately linked. Although psychological stress is
known to modulate immune function, mechanistic pathways linking stress networks in the …

Nociceptive pain is a hallmark of many chronic inflammatory conditions including
inflammatory bowel diseases (IBDs); however, whether pain-sensing neurons influence …

Food and water are rewarding in part because they satisfy our internal needs,.
Dopaminergic neurons in the ventral tegmental area (VTA) are activated by gustatory …

To understand brain function, it is essential that we discover how cellular signaling specifies
normal and pathological brain function. In this regard, chemogenetic technologies represent …

The hypothalamic arcuate–median eminence complex (Arc-ME) controls energy balance,
fertility and growth through molecularly distinct cell types, many of which remain unknown …

A technology that simultaneously records membrane potential from multiple neurons in
behaving animals will have a transformative effect on neuroscience research,. Genetically …

Social memory consists of two processes: the detection of familiar compared with novel
conspecifics and the detailed recollection of past social episodes. We investigated the …

Background Over the past 20 years, insights from human and mouse genetics have
illuminated the central role of the brain leptin-melanocortin pathway in the control of …