The levels and conformers of alpha‐synuclein are critical in the pathogenesis of Parkinson's
Disease and related synucleinopathies. Homeostatic mechanisms in protein degradation …

Protein misfolding, aggregation and deposition are common disease mechanisms in many
neurodegenerative diseases including Parkinson's disease (PD). Accumulation of damaged …

The upsurge in prevalence of obesity has spawned an epidemic of nonalcoholic fatty liver
disease (NAFLD). Previously, we identified a sequence variant (I148M) in patatin-like …

Parkin is an E3‐ubiquitin ligase belonging to the RBR (RING–InBetweenRING–RING
family), and is involved in the neurodegenerative disorder Parkinson's disease. Autosomal …

Synucleinopathies, such as Parkinson's disease and diffuse Lewy body disease, are
progressive neurodegenerative disorders characterized by selective neuronal death …

The presence of α-synuclein aggregates in the characteristic Lewy body pathology seen in
idiopathic Parkinson's disease (PD), together with α-synuclein gene mutations in familial PD …

Phosphorylated forms of microtubule-associated protein tau accumulate in neurofibrillary
tangles in Alzheimer's disease. To investigate the effects of specific phosphorylated tau …

While defective α-synuclein homeostasis is central to Parkinson's pathogenesis,
fundamental questions about its degradation remain unresolved. We have developed a …

J. Neurochem.(2008) 104, 1504–1525. Abstract Microglial neuroinflammatory processes
play a primary role in dopaminergic neurodegeneration for Parkinson's disease (PD). This …

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by
nigrostriatal dopaminergic degeneration and development of cytoplasmic inclusions known …