Powerful specialized software is essential for managing, quantifying, and ultimately deriving
scientific insight from results of a microarray experiment. We have developed a suite of …

In just a few years, microarrays have gone from obscurity to being almost ubiquitous in
biological research. At the same time, the statistical methodology for microarray analysis has …

Accumulating data suggest that metastatic dissemination often occurs early during tumour
formation, but the mechanisms of early metastatic spread have not yet been addressed …

Motivation: Microarray data must be background corrected to remove the effects of non-
specific binding or spatial heterogeneity across the array, but this practice typically causes …

MicroRNAs (miRNAs) regulate cell physiology by altering protein expression, but the biology
of platelet miRNAs is largely unexplored. We tested whether platelet miRNA levels were …

DNA microarrays are an important technology for studying gene expression. With a single
hybridization, the level of expression of thousands of genes, or even an entire genome, can …

Microarray technology is a powerful approach for genomics research. The multi-step, data-
intensive nature of this technology has created an unprecedented informatics and analytical …

This chapter is a rough map of the book. It provides a concise overview of data-analytic tasks
associated with microarray studies, pointers to chapters that can help perform these tasks …

Interest in microarrays has increased considerably in the last ten years. This increase in the
use of microarray technology has led to the need for good standards of microarray …

The skeleton is a preferred site of metastasis in patients with disseminated breast cancer.
We have used 4T1 mouse mammary carcinoma cells, which metastasize to bone from the …