Antimicrobial peptides: classification, design, application and research progress in multiple fields

Y Huan, Q Kong, H Mou, H Yi - Frontiers in microbiology, 2020 - frontiersin.org
Antimicrobial peptides (AMPs) are a class of small peptides that widely exist in nature and
they are an important part of the innate immune system of different organisms. AMPs have a …

The multifaceted nature of antimicrobial peptides: Current synthetic chemistry approaches and future directions

BH Gan, J Gaynord, SM Rowe, T Deingruber… - Chemical Society …, 2021 - pubs.rsc.org
Bacterial infections caused by 'superbugs' are increasing globally, and conventional
antibiotics are becoming less effective against these bacteria, such that we risk entering a …

Designing antimicrobial peptides: form follows function

CD Fjell, JA Hiss, REW Hancock… - Nature reviews Drug …, 2012 - nature.com
Multidrug-resistant bacteria are a severe threat to public health. Conventional antibiotics are
becoming increasingly ineffective as a result of resistance, and it is imperative to find new …

Mechanistic landscape of membrane-permeabilizing peptides

S Guha, J Ghimire, E Wu, WC Wimley - Chemical reviews, 2019 - ACS Publications
Membrane permeabilizing peptides (MPPs) are as ubiquitous as the lipid bilayer
membranes they act upon. Produced by all forms of life, most membrane permeabilizing …

Antimicrobial peptides: key components of the innate immune system

M Pasupuleti, A Schmidtchen… - Critical reviews in …, 2012 - Taylor & Francis
Life-threatening infectious diseases are on their way to cause a worldwide crisis, as treating
them effectively is becoming increasingly difficult due to the emergence of antibiotic resistant …

Characterization of antimicrobial peptides toward the development of novel antibiotics

W Aoki, M Ueda - Pharmaceuticals, 2013 - mdpi.com
Antimicrobial agents have eradicated many infectious diseases and significantly improved
our living environment. However, abuse of antimicrobial agents has accelerated the …

Peptides and peptidomimetics for antimicrobial drug design

B Mojsoska, H Jenssen - Pharmaceuticals, 2015 - mdpi.com
The purpose of this paper is to introduce and highlight a few classes of traditional
antimicrobial peptides with a focus on structure-activity relationship studies. After first …

DADP: the database of anuran defense peptides

M Novković, J Simunić, V Bojović, A Tossi… - …, 2012 - academic.oup.com
Anuran tissues, and especially skin, are a rich source of bioactive peptides and their
precursors. We here present a manually curated database of antimicrobial and other …

New trends in peptide-based anti-biofilm strategies: a review of recent achievements and bioinformatic approaches

P Jorge, A Lourenco, MO Pereira - Biofouling, 2012 - Taylor & Francis
Antimicrobial peptides (AMPs) have a broad spectrum of activity and unspecific mechanisms
of action. Therefore, they are seen as valid alternatives to overcome clinically relevant …

Bioinformatic analysis of 1000 amphibian antimicrobial peptides uncovers multiple length-dependent correlations for peptide design and prediction

G Wang - Antibiotics, 2020 - mdpi.com
Amphibians are widely distributed on different continents, except for the polar regions. They
are important sources for the isolation, purification and characterization of natural …