Microglia shape the synaptic environment in health and disease, but synapses do not exist
in a vacuum. Instead, pre-and postsynaptic terminals are surrounded by extracellular matrix …

Fast-spiking parvalbumin (PV) interneurons are inhibitory interneurons with unique
morphological and functional properties that allow them to precisely control local circuitry …

Background Microglia, the brain's principal immune cell, are increasingly implicated in
Alzheimer's disease (AD), but the molecular interfaces through which these cells contribute …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized clinically by severe
cognitive deficits and pathologically by amyloid plaques, neuronal loss, and neurofibrillary …

During restricted time windows of postnatal life, called critical periods, neural circuits are
highly plastic and are shaped by environmental stimuli. In several mammalian brain areas …

Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer's disease (AD),
increasing risk and decreasing age of disease onset. Many studies have demonstrated the …

Early and progressive dysfunctions of the dopaminergic system from the Ventral Tegmental
Area (VTA) have been described in Alzheimer's Disease (AD). During the long pre …

Perineuronal nets (PNNs) are chondroitin-sulfate glycosaminoglycan (CS-GAG) containing
extracellular matrix structures that assemble around neurons involved in learning, memory …

Memory disruption in mild cognitive impairment (MCI) and Alzheimer9s disease (AD) is
poorly understood, particularly at early stages preceding neurodegeneration. In mouse …

A growing body of evidence has demonstrated a link between Alzheimer disease (AD) and
epilepsy. Late-onset epilepsy and epileptiform activity can precede cognitive deterioration in …