The endocannabinoid system: a potential target for the treatment of various diseases

H Lowe, N Toyang, B Steele, J Bryant… - International journal of …, 2021 - mdpi.com
The Endocannabinoid System (ECS) is primarily responsible for maintaining homeostasis, a
balance in internal environment (temperature, mood, and immune system) and energy input …

The tempted brain eats: pleasure and desire circuits in obesity and eating disorders

KC Berridge, CY Ho, JM Richard, AG DiFeliceantonio - Brain research, 2010 - Elsevier
What we eat, when and how much, all are influenced by brain reward mechanisms that
generate “liking” and “wanting” for foods. As a corollary, dysfunction in reward circuits might …

'Liking'and 'wanting'food rewards: brain substrates and roles in eating disorders

KC Berridge - Physiology & behavior, 2009 - Elsevier
What brain reward systems mediate motivational 'wanting'and hedonic 'liking'for food
rewards? And what roles do those systems play in eating disorders? This article surveys …

The emerging role of the endocannabinoid system in endocrine regulation and energy balance

U Pagotto, G Marsicano, D Cota, B Lutz… - Endocrine …, 2006 - academic.oup.com
During the last few years, the endocannabinoid system has emerged as a highly relevant
topic in the scientific community. Many different regulatory actions have been attributed to …

Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: stimulation of eating by 2‐arachidonoyl glycerol

TC Kirkham, CM Williams, F Fezza… - British journal of …, 2002 - Wiley Online Library
Endocannabinoids are implicated in appetite and body weight regulation. In rodents,
anandamide stimulates eating by actions at central CB1 receptors, and hypothalamic …

CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity

C Ravinet Trillou, C Delgorge, C Menet… - International journal of …, 2004 - nature.com
OBJECTIVE: There is growing evidence for an implication of the CB1 receptor subtype of the
endocannabinoid system in the regulation of eating and fat deposition. To further define the …

Hedonic hot spots in the brain

S Peciña, KS Smith, KC Berridge - The Neuroscientist, 2006 - journals.sagepub.com
Hedonic “liking” for sensory pleasures is an important aspect of reward, and excessive
'liking'of particular rewards might contribute to excessive consumption and to disorders such …

Anti-obesity effect of SR141716, a CB1 receptor antagonist, in diet-induced obese mice

C Ravinet Trillou, M Arnone… - American Journal …, 2003 - journals.physiology.org
Because the CB1 receptor antagonist SR141716 was previously reported to modulate food
intake in rodents, we studied its efficacy in reducing obesity in a diet-induced obesity (DIO) …

Liking vs. wanting food: importance for human appetite control and weight regulation

G Finlayson, N King, JE Blundell - Neuroscience & Biobehavioral Reviews, 2007 - Elsevier
Current train of thought in appetite research is favouring an interest in non-homeostatic or
hedonic (reward) mechanisms in relation to overconsumption and energy balance. This …

Ligands that target cannabinoid receptors in the brain: from THC to anandamide and beyond

RG Pertwee - Addiction biology, 2008 - Wiley Online Library
ABSTRACT A major finding—that (–)‐trans‐Δ9‐tetrahydrocannabinol (Δ9‐THC) is largely
responsible for the psychotropic effects of cannabis—prompted research in the 1970s and …