Preeclampsia (PE) is an often fatal pathology characterized by hypertension and proteinuria
at the 20th week of gestation that affects 5–10% of the pregnancies. The problem is …

The etiology of preeclampsia is unknown. At present, 4 hypotheses are the subject of
extensive investigation, as follows:(1) Placental ischemia—Increased trophoblast …

Pregnancy is a state of oxidative stress arising from increased placental mitochondrial
activity and production of reactive oxygen species (ROS), mainly superoxide anion. The …

This review will consider whether nitric oxide (NO) contributes to maternal systemic
vasodilation during pregnancy, regulates uterine and fetoplacental blood flow, and is …

Pre-eclampsia, a syndrome of pregnant women, is one of the leading causes of maternal
and fetal morbidity and mortality. Despite active research, the etiology of this disorder …

Preeclampsia, a pregnancy‐specific syndrome characterized by hypertension, proteinuria
and edema, resolves on delivery of the placenta. Normal pregnancy is itself characterized by …

In preeclampsia, poor placental perfusion may result in maternal endothelial dysfunction, but
the pathways involved are largely unknown. Candidate placental mediators include …

The adaptation of vascular tone in early pregnancy precedes and probably triggers blood
volume and cardiac output increase. Because the endothelium is known to regulate vascular …

Nitric oxide has a tantalizing role in health and disease: while many of its wide-ranging
effects are well known, there remains much more to explore and to learn about the …

During early human pregnancy extravillous cytotrophoblasts invade the uterus and also
migrate up the spiral arteries, transforming them into large vessels of low resistance. Failure …