Recent advances have driven the development of stem cell-derived, self-organizing, three-
dimensional miniature organs, termed organoids, which mimic different eye tissues …

Destruction of the limbus and depletion of limbal stem cells (LSCs), the adult progenitors of
the corneal epithelium, leads to limbal stem cell deficiency (LSCD). LSCD is a rare …

Corneal failure is a highly prevalent cause of blindness. One special cause of corneal failure
occurs due to malfunction or destruction of the limbal stem cell niche, upon which the …

Limbal stem cells constitute an important cell population required for regeneration of the
corneal epithelium. If insults to limbal stem cells or their niche are sufficiently severe, a …

Abstract ENGLISH SUMMARY Dry eye disease (DED) is characterized by ocular dryness,
irritation and blurred vision and has a significant impact on the patient's quality of life. This …

Background Differentiation of functional limbal stem cells (LSCs) from human pluripotent
stem cells (hPSCs) is an important objective which can provide novel treatment solutions for …

Limbal stem cells (LSCs) are already used in cell‐based treatments for ocular surface
disorders. Clinical translation of LSCs‐based therapies critically depends on the successful …

The corneal epithelium is composed of nonkeratinized stratified squamous cells and has a
significant turnover rate. Limbal integrity is vital to maintain the clarity and avascularity of the …

The future of keratoplasty: cell-based therapy, regenerative... : Current Opinion in Ophthalmology
The future of keratoplasty: cell-based therapy, regenerative medicine, bioengineering …

Lacrimal gland plays a vital role in maintaining the health and function of the ocular surface.
Dysfunction of the gland leads to disruption of ocular surface homeostasis and can lead to …