Gradual disclosure of the molecular basis of selective neuronal apoptosis during
neurodegenerative diseases reveals active participation of acetylating and deacetylating …

Evaluation of the chronic effects of spinal cord injury (SCI) has long focused on sensorimotor
deficits, neuropathic pain, bladder/bowel dysfunction, loss of sexual function, and emotional …

MicroRNA (miRNA) functions in the pathogenesis of major neurodegenerative diseases
such as Alzheimer's disease (AD) are only beginning to emerge. We have observed …

The mechanisms leading to degeneration of dopaminergic neurons (DNs) in the substantia
nigra of patients with Parkinson's disease (PD) are not completely understood. Here, we …

The ubiquitin ligase anaphase-promoting complex (APC) recruits the coactivator Cdc20 to
drive mitosis in cycling cells. However, the nonmitotic functions of Cdc20-APC have …

Nerve cells that re-enter a cell cycle will die rather than divide, a fact that likely underlies the
neurodegeneration in Alzheimer's disease (AD). Several mouse models of familial AD have …

Spinal cord injury (SCI) causes delayed secondary biochemical alterations that lead to
tissue loss and associated neurological dysfunction. Up-regulation of cell cycle proteins …

HDAC4 is a Class II histone deacetylase (HDAC) that is highly expressed in the brain, but
whose functional significance in the brain is not known. We show that forced expression of …

Cell cycle events have been documented to be associated with several human
neurodegenerative diseases. This review focuses on two diseases–Alzheimer's disease and …

Cellular senescence, a stress‐induced irreversible cell cycle arrest, has been defined for
mitotic cells and is implicated in aging of replicative tissues. Age‐related functional decline …