Vascular endothelial growth factor receptors (VEGFRs) are a family of receptor protein
tyrosine kinases that play an important role in the regulation of tumor-induced angiogenesis …

Breast cancer is the most common cancer and the most frequent cause of cancer death
among women worldwide. Breast cancer is a complex, heterogeneous disease classified …

Due to the complexity of multifactorial diseases, single-target drugs do not always exhibit
satisfactory efficacy. Recently, increasing evidence indicates that simultaneous modulation …

Vascular epidermal growth factor receptor-2 (VEGFR-2), as an important tyrosine
transmembrane protein, plays an important role in regulating endothelial cell proliferation …

The dominant paradigm in drug discovery is to design ligands with maximum selectivity to
act on individual drug targets. With the target-based approach, many new chemical entities …

Estrogen receptors (ERs) are a group of compounds named for their importance in both
menstrual and estrous reproductive cycles. They are involved in the regulation of various …

Epoxides as alkylating reagents are unprecedentedly applied in Pd (II)-catalyzed C–H
alkylation and oxidative annulation of substituted benzamides to synthesize isoquinolones …

Estrogen receptor alpha (ERα), a nuclear transcription factor, is a well-validated therapeutic
target for more than 70% of all breast cancers (BCs). Antagonizing ERα either by selective …

The marine environment is an excellent resource for natural products with therapeutic
potential. Its microbial inhabitants, often associated with other marine organisms, are …

A convenient pathway to a new series of α-CF3-substituted α-amino acid derivatives bearing
pharmacophore isoquinolone core in their backbone has been developed. The method is …