Cell death in chronic inflammation: breaking the cycle to treat rheumatic disease

H Anderton, IP Wicks, J Silke - Nature Reviews Rheumatology, 2020 - nature.com
Cell death is a vital process that occurs in billions of cells in the human body every day. This
process helps maintain tissue homeostasis, supports recovery from acute injury, deals with …

Cardiovascular risk in ankylosing spondylitis and the effect of anti-TNF drugs: a narrative review

F Atzeni, V Nucera, J Galloway, S Zoltán… - Expert opinion on …, 2020 - Taylor & Francis
Introduction: Cardiovascular (CV) mortality is increased in patients with ankylosing
spondylitis (AS), but little is known about CV morbidity beyond the fact that they have a two …

[HTML][HTML] Long-term safety of secukinumab over five years in patients with moderate-to-severe plaque psoriasis, psoriatic arthritis and ankylosing spondylitis: update on …

AB Gottlieb, A Deodhar, IB Mcinnes… - Acta dermato …, 2022 - ncbi.nlm.nih.gov
Secukinumab, a selective interleukin (IL)-17A inhibitor, is approved for use in adult and
paediatric psoriasis, psoriatic arthritis, ankylosing spondylitis and non-radiographic axial …

MACE and VTE across upadacitinib clinical trial programmes in rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis

C Charles-Schoeman, E Choy, IB McInnes, E Mysler… - RMD open, 2023 - rmdopen.bmj.com
Objectives To provide an integrated analysis of major adverse cardiovascular events
(MACEs) and events of venous thromboembolism (VTE) and associated risk factors across …

Risk of major adverse cardiovascular events in patients initiating biologics/apremilast for psoriatic arthritis: a nationwide cohort study

L Pina Vegas, P Le Corvoisier, L Penso, M Paul… - …, 2022 - academic.oup.com
Abstract Objective Several biological DMARDs (bDMARDs) have demonstrated anti-
inflammatory effects in PsA. However, their comparative cardiovascular safety profiles …

JAK inhibitors and risk of major cardiovascular events or venous thromboembolism: a self-controlled case series study

A Gouverneur, J Avouac, C Prati, JL Cracowski… - European Journal of …, 2022 - Springer
Purpose JAK-inhibitors (JAK-i) might be associated with venous (VTE) and arterial
thromboembolic events (ATE). To evaluate the association between JAK-i and the risk of …

The genesis of cardiovascular risk in inflammatory arthritis: insights into glycocalyx shedding, endothelial dysfunction, and atherosclerosis initiation

AK Angelov, M Markov, M Ivanova, T Georgiev - Clinical Rheumatology, 2023 - Springer
This narrative review provides a comprehensive examination of the complex interplay
between inflammatory arthritis (IA) and cardiovascular pathology. It particularly illuminates …

Impact of NSAIDs on 8-year cumulative incidence of major cardiovascular events in patients with ankylosing spondylitis: a nationwide study

O Fakih, M Desmarets, B Martin, C Prati… - …, 2023 - academic.oup.com
Objectives The objectives of this study were to describe the incidence of major adverse
cardiovascular events (MACEs) in French patients newly benefiting from the French Long …

HLA-B27, axial spondyloarthritis and survival

Z Li, MK Khan, SM van der Linden… - Annals of the …, 2023 - ard.bmj.com
Introduction Ankylosing spondylitis (AS), and carriage of HLA-B27 gene in otherwise healthy
individuals, are reportedly associated with increased mortality. We evaluated this …

Prevalence and pattern of comorbidities in chronic rheumatic and musculoskeletal diseases: the COMORD study

N Ziade, B El Khoury, M Zoghbi, G Merheb… - Scientific reports, 2020 - nature.com
Increased risk of comorbidities has been reported in Rheumatic and Musculoskeletal
Diseases (RMD). We aimed to evaluate the prevalence and pattern of comorbidities in RMD …