An overview of marketed nucleoside and nucleotide analogs
S De Jonghe, P Herdewijn - Current Protocols, 2022 - Wiley Online Library
Nucleos (t) ide chemistry has been the subject of intense research, mainly because of the
promising antiviral and antitumoral activity associated with this compound class. Numerous …
promising antiviral and antitumoral activity associated with this compound class. Numerous …
Strategies for targeting the P2Y12 receptor in the central nervous system
BB Ma, AP Montgomery, B Chen, M Kassiou… - Bioorganic & medicinal …, 2022 - Elsevier
The purinergic 2Y type 12 receptor (P2Y 12 R) is a well-known biological target for anti-
thrombotic drugs due to its role in platelet aggregation and blood clotting. While the …
thrombotic drugs due to its role in platelet aggregation and blood clotting. While the …
3D-QSAR-based pharmacophore modelling of quinazoline derivatives for the identification of acetylcholinesterase inhibitors through virtual screening, molecular …
Alzheimer's disease (AD) is a progressive neurological disorder responsible for the
cognitive dysfunction and cognitive impairment in the patients. Acetylcholinesterase …
cognitive dysfunction and cognitive impairment in the patients. Acetylcholinesterase …
[HTML][HTML] Comprehensive insights into potential roles of purinergic P2 receptors on diseases: Signaling pathways involved and potential therapeutics
Y Guo, T Mao, Y Fang, H Wang, J Yu, Y Zhu… - Journal of Advanced …, 2024 - Elsevier
Background Purinergic P2 receptors, which can be divided into ionotropic P2X receptors
and metabotropic P2Y receptors, mediate cellular signal transduction of purine or pyrimidine …
and metabotropic P2Y receptors, mediate cellular signal transduction of purine or pyrimidine …
QSAR, structure-based pharmacophore modelling and biological evaluation of novel platelet ADP receptor (P2Y 12) antagonist
P2Y12 has a key role in platelet aggregation and thrombus formation via an ADP-induced
platelet activation mechanism. Recently, P2Y12 antagonists have become of great interest …
platelet activation mechanism. Recently, P2Y12 antagonists have become of great interest …
Potential antiplatelet agents with grape seed–backbone polyphenols: computational studies
The study focused on grape seed-derived polyphenols for their antiplatelet, anti-
inflammatory, and fibrinolytic properties through molecular docking and dynamics …
inflammatory, and fibrinolytic properties through molecular docking and dynamics …
Dual Antiplatelet Therapy: Guidance for Nurse Practitioners
S O'Keefe, SK Idzik - The Journal for Nurse Practitioners, 2022 - Elsevier
Long-term dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 inhibitor (clopidogrel,
prasugrel, or ticagrelor) is recommended after acute coronary syndrome (ACS) to reduce the …
prasugrel, or ticagrelor) is recommended after acute coronary syndrome (ACS) to reduce the …
Unlocking the Conformational Changes of P2Y12: Exploring an Acridinone Compound's Effect on Receptor Activity and Conformation
BO Al-Najjar, FG Saqallah - Molecules, 2023 - mdpi.com
The P2Y12 receptor is an important member of the purinergic receptor family, known for its
critical role in platelet activation and thrombosis. In our previously published study, the …
critical role in platelet activation and thrombosis. In our previously published study, the …
[HTML][HTML] Synthesis and Biological Evaluation of Novel Thiadiazole Derivatives as Antiplatelet Agents
M Khakpash, M Esfahanizadeh… - Iranian Journal of …, 2023 - ncbi.nlm.nih.gov
A novel series of thiadiazole compounds was synthesized through the reaction of
thiosemicarbazone intermediates with 2, 3-dichloro-5, 6-dicyano-1, 4-benzoquinone (DDQ) …
thiosemicarbazone intermediates with 2, 3-dichloro-5, 6-dicyano-1, 4-benzoquinone (DDQ) …