Stearoyl-coenzyme A desaturase 1 (SCD1) is a central regulator of fuel metabolism and may
represent a therapeutic target to control obesity and the progression of related metabolic …

Different lipid fractions in humans have characteristic fatty acid profiles and these are
maintained partly through diet and to a lesser extent through endogenous synthesis. The …

Apart from its role during labor and lactation, oxytocin is involved in several other functions.
Interestingly, oxytocin-and oxytocin receptor-deficient mice develop late-onset obesity with …

Key points• Resveratrol, an antioxidant found in red wine, has beneficial effects on cardiac
and skeletal muscle function, similar to the effects of endurance exercise training.• …

The peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) is a
central modulator of cell metabolism. It regulates mitochondrial biogenesis and oxidative …

Ectopic fat accumulation has been linked to lipotoxic events, including the development of
insulin resistance in skeletal muscle. Indeed, intramyocellular lipid storage is strongly …

Relative to diets enriched in palmitic acid (PA), diets rich in oleic acid (OA) are associated
with reduced risk of type 2 diabetes. To gain insight into mechanisms underlying these …

High-fat diets (HFDs) have been shown to interfere with skeletal muscle energy metabolism
and cause peripheral insulin resistance. However, understanding of HFD impact on skeletal …

Calorie restriction (CR) decreases adiposity, but the magnitude and defense of weight loss
is less than predicted due to reductions in total daily energy expenditure (TEE). The purpose …

Abstract Stearoyl-CoA desaturase (SCD), a central enzyme in lipid metabolism that
synthesizes monounsaturated fatty acids, has been linked to tissue metabolism and body …