In patients with multiple sclerosis (MS), grey matter damage is widespread and might
underlie many of the clinical symptoms, especially cognitive impairment. This relation …

Neuropsychiatric abnormalities may be broadly divided in two categories: disorders of
mood, affect, and behavior and abnormalities affecting cognition. Among these conditions …

The hippocampus has a pivotal role in learning and in the formation and consolidation of
memory and is critically involved in the regulation of emotion, fear, anxiety, and stress …

Background Neuropsychological deficits in patients with multiple sclerosis (MS) have been
shown to be associated with the major pathological substrates of the disease, ie …

Multiple sclerosis (MS) is a chronic, progressive disease of the central nervous system that is
characterised by inflammatory damage to the myelin sheath. Though often neglected …

During the past 10 years, the intense involvement of the grey matter of the CNS in the
pathology of multiple sclerosis has become evident. On gross inspection, demyelination in …

Abstract Objective: Multiple Sclerosis (MS) is an inflammatory demyelinating disease of the
human central nervous system. Although the clinical impact of gray matter pathology in MS …

Diffusion tensor imaging (DTI) measures have shown to be sensitive to white matter (WM)
damage in multiple sclerosis (MS), not only inside focal lesions but also in user-defined …

Owing to its ability to depict the pathologic features of multiple sclerosis (MS) in exquisite
detail, conventional magnetic resonance (MR) imaging has become an established tool in …

Some of the clinical manifestations of multiple sclerosis, such as memory impairment and
depression, are, at least partly, related to involvement of the hippocampus. Pathological …